Abstract
Purpose of Review
This study aims to discuss possible reasons why research to date has not forged direct links between light at night, acute melatonin suppression or circadian disruption, and risks for disease.
Recent Findings
Data suggest that irregular light–dark patterns or light exposures at the wrong circadian time can lead to circadian disruption and disease risks. However, there remains an urgent need to (1) specify light stimulus in terms of circadian rather than visual response; (2) when translating research from animals to humans, consider species-specific spectral and absolute sensitivities to light; (3) relate the characteristics of photometric measurement of light at night to the operational characteristics of the circadian system; and (4) examine how humans may be experiencing too little daytime light, not just too much light at night.
Summary
To understand the health effects light-induced circadian disruption, we need to measure and control light stimulus during the day and at night.
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References
Papers of particular interest, published recently, have been highlighted as: • Of importance
Turek FW. Circadian clocks: not your grandfather’s clock. Science. 2016;354(6315):992–3.
Stephan FK, Zucker I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalmaic lesions. Proc Natl Acad Sci U S A. 1972;69:1583–6.
Klein DC, Moore RY, Reppert SM. Suprachiasmatic nucleus: the mind’s clock. New York: Oxford University Press; 1991.
Ebihara S, Tsuji K. Entrainment of the circadian activity rhythm to the light cycle: effective light intensity for a Zeitgeber in the retinal degenerate C3H mouse and the normal C57BL mouse. Physiol Behav. 1980;24(3):523–7.
Foster R, Provencio I, Hudson D, et al. Circadian photoreception in the retinally degenerate mouse (rd/rd). J Comp Physiol A. 1991;169(1):39–50.
Berson D, Dunn F, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002;295(5557):1070–3.
Provencio I, Rodriguez IR, Jiang G, Hayes WP, Moreira EF, Rollag MD. A novel human opsin in the inner retina. J Neurosci. 2000;20(2):600–5.
Hattar S, Lucas RJ, Mrosovsky N, Thompson SH, Douglas RH, Hankins MW, et al. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature. 2003;424:75–81.
Ruby N, Brennan T, Xie X. Role of melanopsin in circadian responses to light. Science. 2002;298:2211–3.
Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, et al. Melanopsin is required for non-image-forming photic responses in blind mice. Science. 2003;301(5632):525–7.
Panda S, Hogenesch JB. It’s all in the timing: many clocks, many outputs. J Biol Rhythm. 2004;19:374–87.
Partch CL, Green CB, Takahashi JS. Molecular architecture of the mammalian circadian clock. Trends Cell Biol. 2014;24(2):90–9.
Lim C, Allada R. Emerging roles for post-transcriptional regulation in circadian clocks. Nat Neurosci. 2013;16(11):1544–50.
Arendt J. Melatonin and the mammalian pineal gland. London: Chapman & Hall; 1994.
Haus E, Smolensky M. Biological clocks and shift work: circadian dysregulation and potential long-term effects. Cancer Causes Control. 2006;17(4):489–500.
Sahar S, Sassone-Corsi P. Metabolism and cancer: the circadian clock connection. Nat Rev Cancer. 2009;9(12):886–96.
Blask DE, Dauchy RT, Sauer LA. Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal. Endocrine. 2005;27(2):179–88.
Filipski E, King VM, Li X, Granda TG, Mormont M-C, Claustrat B, et al. Disruption of circadian coordination accelerates malignant growth in mice. Pathol Biol (Paris). 2003;51(4):216–9.
Filipski E, Delaunay F, King VM, Wu MW, Claustrat B, Grechez-Cassiau A, et al. Effects of chronic jet lag on tumor progression in mice. Cancer Res. 2004;64(21):7879–85.
Stevens RG, Blask DE, Brainard GC, Hansen J, Lockley SW, Provencio I, et al. Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases. Environ Health Perspect. 2007;115(9):1357–62.
Kolstad HA. Nightshift work and risk of breast cancer and other cancers–a critical review of the epidemiologic evidence. Scand J Work Env Hea. 2008;34(1):5–22.
• Kamdar BB, Tergas AI, Mateen FJ, Bhayani NH, Oh J. Night-shift work and risk of breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2013;138(1):291–301. This review of 15 studies concludes that only weak evidence supports the association between night-shift work and increased risk for breast cancer
World Health Organization (WHO) International Agency for Research on Cancer (IARC). IARC monographs on the evaluation of carcinogenic risks to humans: painting, firefighting, and shiftwork. Lyon: World Health Organization (WHO); 2010.
Åkerstedt T, Knutsson A, Narusyte J, Svedberg P, Kecklund G, Alexanderson K. Night work and breast cancer in women: a Swedish cohort study. BMJ Open. 2015;5(4):e008127.
Bonde JP, Hansen J, Kolstad HA, Mikkelsen S, Olsen JH, Blask DE, et al. Work at night and breast cancer-report on evidence-based options for preventive actions. Scand J Work Environ Health. 2012;38(4):380–90.
Cordina-Duverger E, Koudou Y, Truong T, Arveux P, Kerbrat P, Menegaux F, et al. Night work and breast cancer risk defined by human epidermal growth factor receptor-2 (HER2) and hormone receptor status: a population-based case-control study in France. Chronobiol Int. 2016:1–5.
Lin Y, Nishiyama T, Kurosawa M, Tamakoshi A, Kubo T, Fujino Y, et al. Association between shift work and the risk of death from biliary tract cancer in Japanese men. BMC Cancer. 2015;15:757.
Lin X, Chen W, Wei F, Ying M, Wei W, Xie X. Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies. Sleep Med. 2015;16(11):1381–7.
Papantoniou K, Castaño-Vinyals G, Espinosa A, Aragonés N, Pérez-Gómez B, Ardanaz E, et al. Breast cancer risk and night shift work in a case-control study in a Spanish population. Eur J Epidemiol. 2016;31(9):867–78.
Gradisar M, Wolfson AR, Harvey AG, Hale L, Rosenberg R, Czeisler CA. The sleep and technology use of Americans: findings from the National Sleep Foundation’s 2011 Sleep in America Poll. J Clin Sleep Med. 2013;9(12):1291–9.
Wood B, Rea MS, Plitnick B, Figueiro MG. Light level and duration of exposure determine the impact of self-luminous tablets on melatonin suppression. Appl Ergon. 2013;44(2):237–40.
Hysing M, Pallesen S, Stormark KM, Jakobsen R, Lundervold AJ, Sivertsen B. Sleep and use of electronic devices in adolescence: results from a large population-based study. BMJ Open. 2015;5(1):e006748.
Gamble AL, D’Rozario AL, Bartlett DJ, Williams S, Bin YS, Grunstein RR, et al. Adolescent sleep patterns and night-time technology use: results of the Australian Broadcasting Corporation’s Big Sleep Survey. PLoS One. 2014;9(11):e111700.
Falbe J, Davison K, Franckle R, Ganter C, Gortmaker SL, Smith L, et al. Sleep duration, restfulness, and screens in the sleep environment. Pediatrics. 2015;135(2):e367–e75.
Rångtell FH, Ekstrand E, Rapp L, Lagermalm A, Liethof L, Búcaro MO, et al. Two hours of evening reading on a self-luminous tablet vs. reading a physical book does not alter sleep after daytime bright light exposure. Sleep Med. 2016;23:111–8.
Rea MS, editor. IESNA lighting handbook: reference and application. 9th ed. New York, NY: Illuminating Engineering Society of North America; 2000.
Rea MS, Bullough JD, Figueiro MG. Phototransduction for human melatonin suppression. J Pineal Res. 2002;32(4):209–13.
Brainard GC, Hanifin JP, Greeson JM, Byrne B, Glickman G, Gerner E, et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci. 2001;21(16):6405–12.
Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol. 2001;535(1):261–7.
Commission Internationale de l’Éclairage. Light as a true visual quantity: principles of measurement. Paris: Commission Internationale de l’Éclairage; 1978.
• Lucas RJ, Peirson SN, Berson DM, Brown TM, Cooper HM, Czeisler CA, et al. Measuring and using light in the melanopsin age. Trends Neurosci. 2014;37(1):1–9. This study proposed a toolbox allowing researchers to report the effective irradiance experienced by each of the rod, cone, and ipRGCs photoreceptors involved in non-visual responses. While this toolbox is helpful for equating the stimulus–response relationships employed in different studies, it provides no indication of the circadian system’s response to light stimulus
Rea MS, Figueiro MG, Bullough JD, Bierman A. A model of phototransduction by the human circadian system. Brain Res Rev. 2005;50(2):213–28.
Rea MS, Figueiro MG, Bierman A, Hamner R. Modelling the spectral sensitivity of the human circadian system. Light Res Technol. 2012;44(4):386–96.
Jewett ME, Rimmer DW, Duffy JF, Klerman EB, Kronauer RE, Czeisler CA. Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Am J Phys. 1997;273(42):1800–9.
Figueiro MG, Wood B, Plitnick B, Rea MS. The impact of light from computer monitors on melatonin levels in college students. Neuro Endocrinol Lett. 2011;32(2):158–63.
McIntyre IM, Norman TR, Burrows GD, Armstrong SM. Human melatonin suppression by light is intensity dependent. J Pineal Res. 1989;6(2):149–56.
• Figueiro MG. Individually tailored light intervention through closed eyelids to promote circadian alignment and sleep health. Sleep Health. 2015;1(1):75–82. This field study demonstrated the feasibility of using light through closed eyelids during sleep for promoting circadian alignment and sleep health
Zeitzer JM, Fisicaro RA, Ruby NF, Heller HC. Millisecond flashes of light phase delay the human circadian clock during sleep. J Biol Rhythm. 2014;29(5):370–6.
Glickman G, Hanifin JP, Rollag MD, Wang J, Cooper H, Brainard GC. Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonin in humans. J Biol Rhythm. 2003;18(1):71–9.
Visser EK, Beersma DG, Daan S. Melatonin suppression by light in humans is maximal when the nasal part of the retina is illuminated. J Biol Rhythm. 1999;14(2):116–21.
Hebert M, Martin SK, Lee C, Eastman CI. The effects of prior light history on the suppression of melatonin by light in humans. J Pineal Res. 2002;33(4):198–203.
Figueiro MG. Delayed sleep phase disorder: clinical perspective with a focus on light therapy. Nat Sci Sleep. 2016;8:91.
Figueiro MG, Overington D. Self-luminous devices and melatonin suppression in adolescents. Light Res Technol. 2016;46(8):966–75.
Crowley SJ, Cain SW, Burns AC, Acebo C, Carskadon MA. Increased sensitivity of the circadian system to light in early/mid-puberty. J Clin Endocrinol Metab. 2015;100(11):4067–73.
Cissé YM, Peng J, Nelson RJ. Dim light at night prior to adolescence increases adult anxiety-like behaviors. Chronobiol Int. 2016;33(10):1473–80.
Aubrecht TG, Jenkins R, Nelson RJ. Dim light at night increases body mass of female mice. Chronobiol Int. 2015;32(4):557–60.
Fonken LK, Nelson RJ. The effects of light at night on circadian clocks and metabolism. Endocr Rev. 2014;35(4):648–70.
Fonken LK, Finy MS, Walton JC, Weil ZM, Workman JL, Ross J, et al. Influence of light at night on murine anxiety- and depressive-like responses. Behav Brain Res. 2009;205(2):349–54.
Bullough JD, Rea MS, Figueiro MG. Of mice and women: light as a circadian stimulus in breast cancer research. Cancer Causes Control. 2006;17(4):375–83.
Rea MS. Keynote address: light isn't just for vision anymore! Fifth International Lighting Research Symposium on Light and Human Health, Electric Power Research Institute, Lighting Research Office; 2002 November 3–5, 2002; Orlando, FL.
Jacobs GH, Williams GA, Fenwick JA. Influence of cone pigment coexpression on spectral sensitivity and color vision in the mouse. Vis Res. 2004;44(14):1615–22.
Wright H, Lack L. Effect of light wavelength on suppression and phase delay of the melatonin rhythm. Chronobiol Int. 2001;18(5):801–8.
Reiter R. Action spectra, dose-response relationships, and temporal aspects of light’s effects on the pineal gland. Annal NY Acad Sci. 1985;453:215–30.
Lewy AJ, Wehr TA, Goodwin FK, Newsome DA. Light suppresses melatonin secretion in humans. Science. 1980;210(4475):1267–9.
McIntyre IM, Norman TR, Burrows GD, Armstrong SM. Quantal melatonin suppression by exposure to low intensity light in man. Life Sci. 1989;45(4):327–32.
Kloog I, Haim A, Stevens RG, Barchana M, Portnov BA. Light at night co-distributes with incident breast but not lung cancer in the female population of Israel. Chronobiol Int. 2008;25:65–81.
Kloog I, Stevens RG, Haim A, Portnov BA. Nighttime light level co-distributes with breast cancer incidence worldwide. Cancer Causes Control. 2010;21(12):2059–68.
Kloog I, Portnov BA, Rennert HS, Haim A. Does the modern urbanized sleeping habitat pose a breast cancer risk? Chronobiol Int. 2011;28:76–80.
Keshet-Sitton A, Or-Chen K, Huber E, Haim A. Illuminating a risk for breast cancer: a preliminary ecological study on the association between streetlight and breast cancer. Integr Cancer Ther. 2016;
Brainard GC, Sliney D, Hanifin JP, Glickman G, Byrne B, Greeson JM, et al. Sensitivity of the human circadian system to short-wavelength (420-nm) light. J Biol Rhythm. 2008;23(5):379–86.
Glickman G, Levin R, Brainard GC. Ocular input for human melatonin regulation: relevance to breast cancer. Neuro Endocrinol Lett. 2002;23(supplement 2):17–22.
Kozaki T, Koga S, Toda N, Noguchi H, Yasukouchi A. Effects of short wavelength control in polychromatic light sources on nocturnal melatonin secretion. Neurosci Lett. 2008;439(3):256–9.
Ziskin D. OLS #16 acceptance test report, CDRL 066A2, digitized by Fabio Falchi. Personal communication, December 2010. F16 tabular data provided by Mr. Ziskin, Cooperative Institute for Research in Environmental Sciences (CIRES), National Oceanic and Atmospheric Administration (NOAA), National Geophysical Data Center (NGDC), National Geophysical Data Center, Westinghouse Electric Corporation, 1990.
Mermilliod JC, Hauck B, Mermilliod M. The general catalogue of photometric data, Institut d’Astronomie de l’Universite de Lausanne, Versoix, Switzerland: observatoire de Genève; 2008. http://obswww.unige.ch/gcpd/filters/fil01.html. Accessed 18 Jan 2017.
Rea MS, Brons JA, Figueiro MG. Measurements of light at night (LAN) for a sample of female school teachers. Chronobiol Int. 2011;28(8):673–80.
• Hunter CM, Figueiro MG. Measuring light at night and melatonin levels in shift workers: a review of the literature. Biol Res Nurs. 2016; In press. This review summarizes research detailing field studies of cancer in human participants, specifically shift workers whose exposure to LAN was quantitatively assessed in some way and whose melatonin (or its metabolites) was quantitatively measured over a relevant period.
Grundy A, Sanchez M, Richardson H, Tranmer J, Borugian M, Graham CH, et al. Light intensity exposure, sleep duration, physical activity, and biomarkers of melatonin among rotating shift nurses. Chronobiol Int. 2009;26(7):1443–61.
Grundy A, Tranmer J, Richardson H, Graham CH, Aronson KJ. The influence of light at night exposure on melatonin levels among Canadian rotating shift nurses. Cancer Epidemiol Biomark Prev. 2011;20(11):2404–12.
Dumont M, Lanctot V, Cadieux-Viau R, Paquet J. Melatonin production and light exposure of rotating night workers. Chronobiol Int. 2012;29(2):203–10.
Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C. Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol. 2000;526(3):695–702.
Bierman A, Klein TR, Rea MS. The daysimeter: a device for measuring optical radiation as a stimulus for the human circadian system. Meas Sci Technol. 2005;16:2292–9.
Figueiro MG, Rea MS, Stevens RG, Rea AC. Daylight and productivity: a possible link to circadian regulation. Light and human health: EPRI/LRO 5th International Lighting Research Symposium, Electric Power Research Institute Lighting Research Office; Palo Alto, CA. 2002. p. 185–93.
• Boubekri M, Cheung I, Reid K, Wang C, Zee P. Impact of windows and daylight exposure on overall health and sleep quality of office workers: a case-control pilot study. J Clin Sleep Med. 2014;10(6):603–11. This study showed that people working in offices without access to windows reported poorer sleep quality, shorter sleep duration, and more-frequent sleep disturbances
Figueiro MG, Steverson B, Heerwagen J, Kampschroer K, Hunter CM, Gonzales K, et al. The impact of daytime light exposures on sleep and mood in office workers. Sleep Health. 2017: In press.
Reddy AB, Wong GK, O’Neill J, Maywood ES, Hastings MH. Circadian clocks: neural and peripheral pacemakers that impact upon the cell division cycle. Mutat Res. 2005;574(1–2):76–91.
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This article was written with the support of a grant from the National Institute for Occupational Safety and Health, No. R01OH010668.
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Figueiro, M.G. Disruption of Circadian Rhythms by Light During Day and Night. Curr Sleep Medicine Rep 3, 76–84 (2017). https://doi.org/10.1007/s40675-017-0069-0
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DOI: https://doi.org/10.1007/s40675-017-0069-0