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Sindrome post-finasteride: tra mito e realtà

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L'Endocrinologo Aims and scope

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Numerosi studi hanno dimostrato l’associazione tra l’uso di finasteride e la comparsa di disfunzioni sessuali e sindrome depressiva, che possono persistere dopo la sospensione del farmaco (Sindrome post-finasteride). I ridotti livelli di DHT e dei metaboliti della 5AR ad azione neuroattiva, in aree del SNC fondamentali per l’attività sessuale e il tono dell’umore, sembrerebbero essere i responsabili della sindrome. In questo lavoro viene caratterizzata la sindrome, al fine di migliorarne la gestione.

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Conflitto di interesse

Gli autori Alessandro Pizzocaro, Giovanna Motta, Luciano Negri e Pierpaolo Graziotti dichiarano di non avere conflitti di interessi.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

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Authors and Affiliations

  1. U.O. Urologia, Servizio di Andrologia, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089, Rozzano, MI, Italia

    Alessandro Pizzocaro & Pierpaolo Graziotti

  2. S.C.D.U. Endocrinologia, Diabetologia e Metabolismo, Dipartimento Scienze Mediche, Università di Torino, Torino, Italia

    Giovanna Motta

  3. U.O. Medicina della Riproduzione, Istituto Clinico Humanitas IRCC, Rozzano, MI, Italia

    Luciano Negri

Authors
  1. Alessandro Pizzocaro
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  2. Giovanna Motta
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  3. Luciano Negri
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  4. Pierpaolo Graziotti
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Corresponding author

Correspondence to Alessandro Pizzocaro.

Additional information

Proposta da Fabio Lanfranco.

Materiale elettronico supplementare

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Pizzocaro, A., Motta, G., Negri, L. et al. Sindrome post-finasteride: tra mito e realtà. L'Endocrinologo 15, 112–117 (2014). https://doi.org/10.1007/s40619-014-0044-7

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  • DOI: https://doi.org/10.1007/s40619-014-0044-7

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