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Thyroid hormones, metabolic syndrome and Vitamin D in middle-aged and older euthyroid subjects: a preliminary study

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Abstract

Aim

To explore the relationship between thyroid hormones, Vitamin D (Vit.D) serum concentrations and metabolic syndrome (MetS) in euthyroid subjects.

Methods

123 community-dwelling subjects were enrolled. According to thyroid-stimulating hormone (TSH) values the sample was divided into: (1) group 1 (TSH ≤ 2 mU/L); (2) group 2 (TSH > 2 mU/L).

Results

Group 2 showed higher percentage of subjects with MetS (p = 0.003) and hypertension (p = 0.031), higher values of waist circumference (WC) (p = 0.007), parathyroid hormone (p = 0.016), glycaemia (p = 0.045), triglycerides (p = 0.034) and free T4 (fT4) (p = 0.013). Correlation analysis showed several weak significant correlations: MetS with TSH (r = 0.202, p = 0.031) and fT3 (r = − 0.206, p = 0.028); THS with body mass index (r = 0.187, p = 0.047) and hypertension (r = 0.199, p = 0.034); Vit.D with WC (r = − 0.185, p = 0.04).

Conclusions

Our results showed a possible association between thyroid hormones and MetS. Visceral fat and insulin resistance may be an interesting link between Vit.D and TSH levels.

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Authors and Affiliations

  1. Division of Gerontology, Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy

    Walter Verrusio & Mauro Cacciafesta

  2. Department of Internal Medicine and Geriatric, “Luigi Vanvitelli” University, Naples, Italy

    Valerio Massimo Magro

  3. Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Rome, Italy

    Alessia Renzi

  4. Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy

    Bruno Casciaro

  5. Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy

    Paola Andreozzi

Authors
  1. Walter Verrusio
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  2. Valerio Massimo Magro
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  3. Alessia Renzi
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  4. Bruno Casciaro
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  5. Paola Andreozzi
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  6. Mauro Cacciafesta
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Corresponding author

Correspondence to Walter Verrusio.

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Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Statement of human and animal rights

All procedures performed in this study which involved human participants were in accordance with our institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Verrusio, W., Magro, V.M., Renzi, A. et al. Thyroid hormones, metabolic syndrome and Vitamin D in middle-aged and older euthyroid subjects: a preliminary study. Aging Clin Exp Res 31, 1337–1341 (2019). https://doi.org/10.1007/s40520-018-1071-1

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  • DOI: https://doi.org/10.1007/s40520-018-1071-1

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