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Adiponectin: possible link between metabolic stress and oxidative stress in the elderly

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Abstract

Objective

The aim of this study was to evaluate the relationships between the serum levels of adiponectin and systemic oxidative stress exerted on lipids, proteins, as well as endothelial function and cardiovascular diseases (CVD) risk markers, in elderly subjects with metabolic syndrome (MS).

Methods

The serum advanced glycation and oxidation protein products, low-density lipoprotein susceptibility to oxidation (oxLDL), nitric oxide metabolic pathway products (NOx), serum lipid peroxidation, as well as total antioxidant/oxidative capacity (TAC/TOC), were analyzed in elderly subjects with MS (n = 44), compared to aged-matched control (n = 39).

Results

We pointed out significantly lower levels of adiponectin in elderly MS subjects concomitantly with significantly higher levels of oxidative stress and CVD risk markers. Significant positive correlations were found between serum adiponectin levels and HDL-cholesterol (p < 0.05) and the total cholesterol/LDL-cholesterol ratio (p < 0.01). Additionally, adiponectin levels were significantly inversely associated with insulin resistance index (HOMA-IR, r = −0.348; p < 0.05) and serum lipid peroxidation (r = −0.337; p < 0.05), and significantly positively with the antioxidant capacity (TAC, r = 0.339; p < 0.05). Conversely, adiponectin levels were significantly negatively (r = −0.310; p < 0.05) associated with serum uric acid concentration.

Conclusions

The major protective role of adiponectin versus stress related to an impaired glucose and lipid metabolism suggests that adiponectin plays a critical role in adiposity-related metabolic stress and redox homeostasis.

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Acknowledgments

The authors are grateful for the support consisting in the opportunity to make use of the equipment obtained under the framework of the EU-FP7 Project “MARK-AGE, European Study to Establish Biomarkers of Human Ageing.” Daniela Gradinaru and Anca Dinischiotu acknowledge the scientific support of the EU-COST Actions on Lipid Peroxidation Associated Disorders (B35 Action) and on Chemistry of Non-Enzymatic Protein Modifications (CM1001 Action).

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Pharmacy, Carol Davila - University of Medicine and Pharmacy, 6 Taian Vuia street, sector 2, 020956, Bucharest, Romania

    Daniela Gradinaru, Denisa Margina & Mihaela Ilie

  2. Ana Aslan - National Institute of Gerontology and Geriatrics, 9 Caldarusani street, sector 1, PO Box 2-4, 011241, Bucharest, Romania

    Claudia Borsa, Cristina Ionescu & Gabriel-Ioan Prada

  3. Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, sector 5, 050107, Bucharest, Romania

    Marieta Costache & Anca Dinischiotu

Authors
  1. Daniela Gradinaru
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  2. Denisa Margina
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  7. Anca Dinischiotu
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Corresponding author

Correspondence to Daniela Gradinaru.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was reviewed and approved by the Ethics Committee of the Ana Aslan—National Institute of Gerontology and Geriatrics (Approval Number 14203/14.09.2015).

Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Gradinaru, D., Margina, D., Borsa, C. et al. Adiponectin: possible link between metabolic stress and oxidative stress in the elderly. Aging Clin Exp Res 29, 621–629 (2017). https://doi.org/10.1007/s40520-016-0629-z

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  • DOI: https://doi.org/10.1007/s40520-016-0629-z

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