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Bone mineral density in geriatric patients with toxic nodular goiter

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Abstract

Background and aims

We aimed to assess bone mineral density (BMD) in geriatric patients with hyperthyroidism caused by TNG.

Materials and methods

Bone mineral density was measured at the lumbar spine and proximal femur, using dual-X-ray absorptiometry (DXA) in 90 patients with TNG (mean age; 69.2± 4.4 years) and compared with those in 42 age-matched healthy subjects (mean age; 68.40 ± 4.3 years). Serum levels of TSH, fT3, fT4, 25-OH vitamin D and PTH were measured.

Results

BMD was significantly lower at total spine (0.904 ± 0.1 vs. 1.114 ± 0.1 g/cm2) and total hip (0.850 ± 0.1 vs. 1.079 ± 0.1 g/cm2) in male patients with TNG in comparison to the healthy men (p = 0.001, p < 0.001). Postmenopausal women with TNG had lower BMD measurements at total lumbar spine (0.754 ± 0.1 vs. 0.870 ± 0.2 g/cm2, p < 0.001) and total hip (0.765 ± 0.1 vs. 0.831 ± 0.2 g/cm2, p < 0.001) in comparison to the healthy women. T scores of total lumbar spine and hip were lower in patients with subclinical hyperthyroidism compared to the control group, respectively (−1.9 ± 1.7 vs −0.8 ± 1.8, p = 0.007; −1.09 ± 1.2 vs. −0.02 ± 1.6, p = 0.001). While serum levels of fT3 and fT4 revealed a negative correlation with T score of BMD measurements at the total spine and hip, TSH levels were positively correlated. We did not find a difference in serum calcium, phosphorus, 25-OH vitamin D and PTH levels between the two groups (p > 0.005).

Conclusion

Geriatric patients with hyperthyroidism secondary to TNG had reduced BMD at the total spine and hip. Thus, we suggest to investigate bone mineral density in geriatric patients with TNG.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University Medical School, 53020, Rize, Turkey

    Serap Baydur Sahin & Ekrem Algun

  2. Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, Rize, Turkey

    Teslime Ayaz, Fatih Sumer & Kadir İlkkilic

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  1. Serap Baydur Sahin
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  2. Teslime Ayaz
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  3. Fatih Sumer
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  4. Kadir İlkkilic
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  5. Ekrem Algun
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Correspondence to Serap Baydur Sahin.

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Sahin, S.B., Ayaz, T., Sumer, F. et al. Bone mineral density in geriatric patients with toxic nodular goiter. Aging Clin Exp Res 27, 221–226 (2015). https://doi.org/10.1007/s40520-014-0269-0

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  • DOI: https://doi.org/10.1007/s40520-014-0269-0

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