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Neural Foundations of Mood-Induced Impulsivity and Impulsive Aggression in Schizophrenia

  • Psychosis (A Ahmed, Section Editor)
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Abstract

Impulsivity is elevated in schizophrenia and is a risk factor for aggression in the disorder, but it is a multidimensional construct. Recently, the impulsivity subconstruct of urgency, which refers to rash action in the face of strong mood states, has been shown to be highly correlated with aggression in schizophrenia, especially impulsive aggression. This review discusses recent neuroimaging findings regarding urgency and its relation to impulsive aggression in schizophrenia. In addition, potential relationships between urgency and emotional regulation are discussed, along with potential treatments for impulsive aggression in schizophrenia that could be developed via a consideration of the urgency construct.

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Notes

  1. Because the construct of positive urgency was developed after negative urgency, there is some confusion in the literature about terminology. In older articles (pre 2008) and even some more recent ones, references to urgency should be taken to mean negative urgency. However, in more recent articles, it is preferable to specify which kind of urgency is meant. Herein, where we do not specify positive or negative, it should be understood that we are referring to both varieties of urgency.

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Acknowledgments

We thank Pamela D. Butler, PhD, for her helpful comments. This work was funded in part by a National Institute of Mental Health grant to MJH (R21MH084031) and a National Alliance for Research in Schizophrenia and Affective Disorders Young Investigator Award grant to AOA (Grant #24137).

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Authors and Affiliations

  1. Schizophrenia Research Division, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd., Bldg. 35, Orangeburg, NY, 10962, USA

    Matthew J. Hoptman

  2. Department of Psychiatry, New York University School of Medicine, 550 First Ave., New York, NY, 10016, USA

    Matthew J. Hoptman

  3. Department of Psychology, City College of the City University of New York, New York, NY, 10031, USA

    Matthew J. Hoptman

  4. Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY, 10605, USA

    Anthony O. Ahmed

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Hoptman, M.J., Ahmed, A.O. Neural Foundations of Mood-Induced Impulsivity and Impulsive Aggression in Schizophrenia. Curr Behav Neurosci Rep 3, 248–255 (2016). https://doi.org/10.1007/s40473-016-0081-6

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