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Association of Rho-kinase 1 (ROCK1) Gene Polymorphisms with Behçet’s Disease

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Abstract

Background and Objective

Behçet’s disease (BD) is a chronic inflammatory vasculitis presenting with flares and silent periods usually between 15 and 40 years of age. The aim of this study was to evaluate the possible association between Rho-kinase 1 (ROCK1) gene polymorphisms and patients with BD in a Turkish population.

Methods

A total of 192 BD patients and 255 healthy controls of similar age and sex were enrolled in this study. Polymorphisms were analyzed in genomic DNA using a BioMark HD dynamic array system.

Results

In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001). There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001). Marked associations between these polymorphisms and the manifestations of BD were recorded.

Conclusion

This is the first study to show that ROCK1 gene polymorphisms may have a significant impact on susceptibility to BD.

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Acknowledgments

This work was financially supported by a grant (BAP TF.10.19) from the University of Gaziantep. Elif Oguz, Abdullah Tuncay Demiryürek, Yavuz Pehlivan, Bünyamin Kisacik, Esma Ozkara, Serdar Oztuzcu, Belgin Alasehirli and Ahmet Mesut Onat declare no conflicts of interest that are directly relevant to the content of this article.

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Authors and Affiliations

  1. Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, University Road, 27310, Sehitkamil, Gaziantep, Turkey

    Elif Oguz, Abdullah Tuncay Demiryürek & Belgin Alasehirli

  2. Department of Medical Pharmacology, Faculty of Medicine, Harran University, Şanlıurfa, Turkey

    Elif Oguz

  3. Department of Rheumatology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey

    Yavuz Pehlivan, Bünyamin Kisacik & Ahmet Mesut Onat

  4. Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey

    Esma Ozkara & Serdar Oztuzcu

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  1. Elif Oguz
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Correspondence to Abdullah Tuncay Demiryürek.

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Oguz, E., Demiryürek, A.T., Pehlivan, Y. et al. Association of Rho-kinase 1 (ROCK1) Gene Polymorphisms with Behçet’s Disease. Mol Diagn Ther 18, 419–426 (2014). https://doi.org/10.1007/s40291-014-0092-5

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