, Volume 1454, Issue 1, p 24
Date: 01 Jun 2013


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Five male and four female infants, aged 1−7 months, were identified from a retrospective chart review of 224 patients after they developed local inflammatory reactions while receiving imiquimod for infantile haemangioma (IH). Four patients were left with permanent depigmented scars.

Seven patients had protuberant IHs, while four patients had skin fold and joint involvement. The patients received topical 5% imiquimod cream, applied every other day to the IH at bedtime. The cream was left on for at least 8 hours before being washed off with mild soap the following morning. The use of imiquimod for haemangioma was off label, and informed consent was obtained before starting treatment. The infants developed local inflammatory reactions during imiquimod treatment, characterised by oedema, erythema, desquamation and the appearance of thick crusts and erosions. Two patients developed small, thin crusts after 2 weeks of therapy, and maximum inflammation was observed in all patients after 3−9 we ...