, Volume 1435, Issue 1, p 6
Date: 19 Jan 2013

Amoxicillin/clavulanic acid

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A 5-year-old boy developed symmetrical drug-related intertriginous and flexural exanthema (SDRIFE or Baboon syndrome) while receiving amoxicillin/clavulanic acid.

The boy was referred due to a 3-day history of a pruritic erythematous eruption. He had started receiving oral amoxicillin/clavulanic acid [dosage not stated] for acute otitis media 2 days before lesion onset. His lesions began to desquamate 1 day after onset. His anogenital area and outer left thigh had desquamation and erythematous macular patches. He had experienced the same rash previously while receiving amoxicillin/clavulanic acid. He was diagnosed with SDRIFE. amoxicillin/clavulanic acid was withdrawn, and the boy's eruption subsequently resolved.

Author comment:"We observed a patient who developed SDRIFE after systemic administration of amoxicillin-[clavulanic acid]."