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Systematic Review of Humanistic and Economic Burden of Symptomatic Chronic Obstructive Pulmonary Disease

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Abstract

Background

An understanding of the humanistic and economic burden of individuals with symptomatic chronic obstructive pulmonary disease (COPD) is required to inform payers and healthcare professionals about the disease burden.

Objectives

The aim of this systematic review was to identify and present humanistic [health-related quality of life (HRQoL)] and economic burdens of symptomatic COPD.

Methods

A comprehensive search of online databases (reimbursement or claims databases/other databases), abstracts from conference proceedings, published literature, clinical trials, medical records, health ministries, financial reports, registries, and other sources was conducted. Adult patients of any race or gender with symptomatic COPD were included. Humanistic and economic burdens included studies evaluating HRQoL and cost and resource use, respectively, associated with symptomatic COPD.

Results

Thirty-two studies reporting humanistic burden and 74 economic studies were identified. Symptomatic COPD led to impairment in the health state of patients, as assessed by HRQoL instruments. It was also associated with high economic burden across all countries. The overall, direct, and indirect costs per patient increased with an increase in symptoms, dyspnoea severity, and duration of disease. Across countries, the annual societal costs associated with symptomatic COPD were higher among patients with comorbidities.

Conclusions

Symptomatic COPD is associated with a substantial economic burden. The HRQoL of patients with symptomatic COPD is, in general, low and influenced by dyspnoea.

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Acknowledgments

Funding for this study was provided by GlaxoSmithKline. All listed authors met the criteria for authorship set forth by the International Committee for Medical Journal Editors. Editorial support, in the form of development, assembling tables and figures, collating author comments, copyediting, fact checking, and referencing, was provided by Dr Annirudha Chillar of Cactus Communications Inc., and was funded by GlaxoSmithKline.

Support and financial disclosure declaration

Funding for this study was provided by GlaxoSmithKline. Yogesh Suresh Punekar is employed by GlaxoSmithKline and owns stocks in the company. Kunal Srivastava, Deepika Thakur, and Sheetal Sharma are employed by Parexel (Heron Health), which was commissioned by GlaxoSmithKline to undertake the research for this systematic review. The authors state that they have full control of all primary data and they agree to allow the journal to review their data if requested.

Author contributions

Kunal Srivastava, Deepika Thakur, and Sheetal Sharma contributed equally in designing the study protocol, methodology, analysis, and manuscript writing. Yoghesh Suresh Punekar contributed in designing the study protocol, methodology, and manuscript writing, and is the overall guarantor for the manuscript.

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Authors and Affiliations

  1. HERON Health PVT (Now Parexel), 3rd Floor, DLF Tower E, Rajiv Gandhi IT Park, Chandigarh, India

    Kunal Srivastava, Deepika Thakur & Sheetal Sharma

  2. Value Evidence and Outcomes, GlaxoSmithKline R&D, Stockley Park West, 1-3 Iron Bridge Road, Uxbridge, Middlesex, UB11 1BT, UK

    Yogesh Suresh Punekar

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  1. Kunal Srivastava
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Correspondence to Yogesh Suresh Punekar.

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Srivastava, K., Thakur, D., Sharma, S. et al. Systematic Review of Humanistic and Economic Burden of Symptomatic Chronic Obstructive Pulmonary Disease. PharmacoEconomics 33, 467–488 (2015). https://doi.org/10.1007/s40273-015-0252-4

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