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Overview of Therapy and Strategies for Optimizing Outcomes in De Novo Pediatric Acute Myeloid Leukemia

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Abstract

Although acute myelogenous leukemia (AML) accounts for <20 % of leukemia in children, it is responsible for over half of all pediatric leukemia deaths. Improvement in event-free survival rates, now over 50 %, are due largely to intensification of chemotherapy, aggressive supportive care, development of risk stratification based on cytogenetic and molecular markers, and improved salvage regimens. Despite this improvement over the past few decades, the survival rates have recently plateaued, and further improvement will need to take into account advances in molecular characterization of AML, development of novel agents, and better understanding of host factors influencing toxicity and response to chemotherapy. This article reviews the epidemiology and biology trends in diagnosis and treatment of pediatric acute myelogenous leukemia.

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Drs. Faulk, Gore, and Cooper have no conflicts of interest to declare. No sources of funding were used in the preparation of this article.

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Authors and Affiliations

  1. Department of Pediatrics, University of Colorado School of Medicine/Anschutz Medical Campus, Aurora, CO, USA

    Kelly Faulk & Lia Gore

  2. Children’s Hospital Colorado, Aurora, CO, USA

    Kelly Faulk & Lia Gore

  3. University of Colorado Cancer Center, Aurora, CO, USA

    Lia Gore

  4. Developmental Therapeutics Program, Aurora, CO, USA

    Lia Gore

  5. Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta/Emory University, Atlanta, GA, USA

    Todd Cooper

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  1. Kelly Faulk
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Faulk, K., Gore, L. & Cooper, T. Overview of Therapy and Strategies for Optimizing Outcomes in De Novo Pediatric Acute Myeloid Leukemia. Pediatr Drugs 16, 213–227 (2014). https://doi.org/10.1007/s40272-014-0067-3

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