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When necessary, use a proven and safe agent to treat hypertension in pregnancy

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Abstract

Chronic and gestational hypertension and preeclampsia fall under the umbrella term ‘hypertension in pregnancy’. These conditions pose important risks for both the mother and the fetus. The aim of pharmacological treatment of hypertension in pregnancy is to prevent maternal complications and ensure that the fetus is unharmed. Therefore, the use of agents with proven efficacy and well-documented tolerability in pregnant patients is recommended.

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References

  1. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183(1):S1–22.

  2. Brown CM, Garovic VD. Drug treatment of hypertension in pregnancy. Drugs. 2014;74(3):283–96.

    Article  PubMed  CAS  Google Scholar 

  3. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122–31.

  4. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31(7):1281–357.

    Article  PubMed  CAS  Google Scholar 

  5. Hypertension in pregnancy: the management of hypertensive disorders during pregnancy. London: NICE 2010. Report No.: CG107.

  6. Lowe SA, Brown MA, Dekker GA, et al. Guidelines for the management of hypertensive disorders of pregnancy 2008. Aust N Z J Obstet Gynaecol. 2009;49(3):242–6.

    Article  PubMed  Google Scholar 

  7. Magee LA, Pels A, Helewa M, et al. Diagnosis, evaluation, management of the the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can. 2014;36(5):416–38.

    PubMed  Google Scholar 

  8. Martin JN Jr, Thigpen BD, Moore RC, et al. Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure. Obstet Gynecol. 2005;105(2):246–54.

    Article  PubMed  Google Scholar 

  9. August P. Preeclampsia: new thoughts on an ancient problem. J Clin Hypertens. 2000;2(2):115–23.

    Google Scholar 

  10. Brown CM, Garovic VD. Mechanisms and management of hypertension in pregnant women. Curr Hypertens Rep. 2011;13:338–46.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Wilson BJ, Watson MS, Prescott GJ, et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326(7394):845.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Smith G, Pell J, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births. Lancet. 2001;357(9273):2002–6.

    Article  PubMed  CAS  Google Scholar 

  13. Jonsdottir LS, Arngrimsson R, Geirsson RT, et al. Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand. 1995;74(10):772–6.

    Article  PubMed  CAS  Google Scholar 

  14. Bateman BT, Hernandez-Diaz S, Huybrechts KF, et al. Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid population. Hypertension. 2012;60(4):913–20.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  15. Duley L, Meher S, Jones L. Drugs for treatment of very high blood pressure during pregnancy. Cochrane Database Syst Rev. 2013;7:CD001449.

    PubMed  Google Scholar 

  16. Duley L, Gulmezoglu AM, Henderson-Smart DJ, et al. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev. 2010;11:CD000025.

    PubMed  Google Scholar 

  17. Duley L, Henderson-Smart DJ, Meher S, et al. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev. 2007;2:CD004659.

    PubMed  Google Scholar 

  18. Hofmeyr GJ, Lawrie TA, Atallah AN, et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev. 2010(8):CD001059.

  19. Roberts JM, Myatt L, Spong CY, et al. Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med. 2010;362(14):1282–91.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Olsen SF, Osterdal ML, Salvig JD, et al. Duration of pregnancy in relation to fish oil supplementation and habitual fish intake: a randomised clinical trial with fish oil. Eur J Clin Nutr. 2007;61(8):976–85.

    Article  PubMed  CAS  Google Scholar 

  21. Magee LA. Drugs in pregnancy. Antihypertensives. Best Pract Res Clin Obstet Gynaecol. 2001;15(6):827–45.

    Article  PubMed  CAS  Google Scholar 

  22. Podymow T, August P. Antihypertensive drugs in pregnancy. Semin Nephrol. 2011;31(1):70–85.

    Article  PubMed  CAS  Google Scholar 

Download references

Disclosure

This article was adapted from Drugs 2014;74(3):283–96 [2] and its preparation was not supported by any external funding. The preparation of the source article [2] was supported by an award from the US National Institute on Aging.

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Adis Medical Writers. When necessary, use a proven and safe agent to treat hypertension in pregnancy. Drugs Ther Perspect 30, 356–360 (2014). https://doi.org/10.1007/s40267-014-0148-y

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  • DOI: https://doi.org/10.1007/s40267-014-0148-y

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