References
Al-Hashimi I, Schifter M, Lockhart P, et al. Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(103 Suppl.):S25.e1–12.
Scully C, El-Kom M. Lichen planus: review and update on pathogenesis. J Oral Pathol. 1985;14:431–58.
Yang H, Wu Y, Ma H, et al. Possible alternative therapies for oral lichen planus cases refractory to steroid therapies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:496–509.
Suresh SS, Chokshi K, Desai S, et al. Medical management of oral lichen planus: a systematic review. J Clin Diagn Res. 2016;10:ZE10–5.
Thongprasom K, Carrozzo M, Furness S, Lodi G. Interventions for treating oral lichen planus. Cochrane Database Syst Rev. 2011;7:CD001168
Eisen D, Ellis CN, Duell EA, et al. Effect of topical cyclosporine rinse on oral lichen planus: a double-blind analysis. N Engl J Med. 1990;23:290–4.
Passeron T, Lacour JP, Fontas E, Ortonne JP. Treatment of oral erosive lichen planus with 1% pimecrolimus cream a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. Arch Dermatol. 2007;143:472–6.
Becker JC, Houben R, Vetter CS, Bröker E. The carcinogenic potential of tacrolimus oinment beyond immune suppression: a hypothesis creating case report. BMC Cancer. 2006;6:7–13.
Sloberg K, Hersie K, Mobacken H, Thilander H. Severe oral lichen planus remissions and maintenance with vitamin A analogues. J Oral Pathol. 1983;12:473–7.
Camisa C, Popovsky JL. Effective treatment of oral erosive lichen planus with thalidomide. Arch Dermatol. 2000;136:1442–3.
Kollner K, Wimmershoff H, Landthaler M, Hohenleutner U. Treatment of oral lichen planus with the 308-nm UVB excimer laser: early preliminary results in eight patients. Lasers Surg Med. 2003;33:158–60.
Cheng A, Nabb C. Oral erosive lichen planus treated with efalizumab. Arch Dermatol. 2006;142:680–2.
Lear JT, English JS. Erosive and generalizad lichen planus responsive to azathioprine. Clin Exp Dermatol. 1996;21:56–7.
Guyot AD, Farhi D, Ingeen-Huesz-Oro S, Bussel A, et al. Treatment of refractory erosive lichen planus with extracorporeal chemotherapy: 12 cases. Br J Dermatol. 2007;156:553–6.
Nousari HC, Goyal S, Anhalt GJ. Successful treatment of resistant hypertrophic and bullous lichen planus with mycophenolate mofetil. Arch Dermatol. 1999;135:1420–1.
Ferguson MM, Simpson NB, Hammersley N. The treatment of erosive lichen planus with a retinoid-etretinate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1984;58:283–7.
EL-Komy MH, Hassan AS, Abdel Raheem HM, et al. Platelet-rich plasma for resistant oral erosions of pemphigus vulgaris: a pilot study. Wound Repair Regen. 2015;23:953–5.
Anitua E, Alkhraisat MH, Orive G. Perspectives and challenges in regenerative medicine using plasma rich in growth factors. J Control Release. 2012;157:29–38.
Anitua E, Murias-Freijo A, Alkhraisat MH, Orive G. Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig. 2015;19:589–600.
Anitua E, Troya M, Orive G. Plasma rich in growth factors promote gingival tissue regeneration by stimulating fibroblast proliferation and migration and by blocking transforming growth factor-β1-induced myodifferentiation. J Periodontol. 2012;83:1028–37.
Zhou L, Cao T, Wang Y, et al. Frequently increased but functionally impaired CD4+CD25+ regulatory T cells in patients with oral lichen planus. Inflammation. 2016;39:1205–15.
Tao XA, Xia J, Chen XB, et al. FOXP3 T regulatory cells in lesions of oral lichen planus correlated with disease activity. Oral Dis. 2010;16:76–82.
Wan YY, Flavell RA. ‘Yin-Yang’ functions of transforming growth factor beta and T regulatory cells in immune regulation. Immunol Rev. 2007;220:199–213.
Cao T, Zhang H, Zhou L, et al. In vitro cell culture system optimization of keratinocytes from oral lichen planus (OLP) patients. Oral Dis. 2017;23:225–32.
Danielsson K, Ebrahimi M, Nylander E, et al. Alterations in factors involved in differentiation and barrier function in the epithelium in oral and genital lichen planus. Acta Derm Venereol. 2017;97:214–8.
Anitua E, Zalduendo MM, Prado R, et al. Morphogen and proinflammatory cytokine release kinetics from PRGF-Endoret fibrin scaffolds: evaluation of the effect of leukocyte inclusion. J Biomed Mater Res A. 2015;103:1011–20.
Anitua E, Zalduendo M, Troya M, Orive G. PRGF exerts a cytoprotective role in zoledronic acid-treated oral cells. Clin Oral Investig. 2016;20:513–21.
Anitua E, Zalduendo M, Troya M, et al. Leukocyte inclusion within a platelet rich plasma-derived fibrin scaffold stimulates a more pro-inflammatory environment and alters fibrin properties. PLoS One. 2015;10:e0121713.
Gunduz K, Demireli P, Inanir I, Nese N. Expression of matrix metalloproteinases (MMP-2, MMP-3, and MMP-9) and fibronectin in lichen planus. J Cutan Pathol. 2006;33:545–50.
Anitua E, Muruzabal F, Pino A, et al. Biological stability of plasma rich in growth factors eye drops after storage of 3 months. Cornea. 2013;32:1380–6.
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Eduardo Anitua is the Scientific Director of BTI Biotechnology Institute (Vitoria, Spain) and the head of the Foundation Eduardo Anitua, Vitoria, Spain. Laura Piñas and Ricardo Suarez Fernández have no conflicts of interest directly relevant to the content of this article. Mohammad Hamdan Alkhraisat is a scientist at BTI Biotechnology Institute (Vitoria, Spain).
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Piñas, L., Alkhraisat, M.H., Fernández, R.S. et al. Biological Therapy of Refractory Ulcerative Oral Lichen Planus with Plasma Rich in Growth Factors. Am J Clin Dermatol 18, 429–433 (2017). https://doi.org/10.1007/s40257-017-0277-x
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DOI: https://doi.org/10.1007/s40257-017-0277-x