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Transcatheter Aortic Valve Replacement: Focus on Sex-Related Differences in Outcomes

  • Review Article
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Abstract

Transcatheter aortic valve replacement (TAVR) has transformed the management of severe aortic stenosis for high-risk and inoperable patients. The 10-year experience in Europe has proven the technology to be safe and effective in select populations. The PARTNER trial, the first prospective, randomized, controlled trial for TAVR, showed the technology to be superior to medical management for inoperable patients and equivalent to surgical aortic valve replacement for high-risk patients. Research in cardiovascular medicine has been dominated by studies on the male sex, due to the incidence of the disease process and partly due to historic predominance of male subjects in research studies. Alternatively, TAVR studies focused on high-risk and inoperable patients who are equally distributed by sex. Although sex-related differences are apparent in their baseline characteristics, outcomes have been mixed, with evidence suggesting that female patients may have a mortality advantage with TAVR. Herein we review the TAVR procedure and devices currently available and focus our discussion on outcomes after transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis.

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Acknowledgments

No external funding was used in the preparation of this review article. KG is on the speaker’s bureau for the Edwards Sapien Valve. MPF has no conflicts of interest that might be relevant to the contents of this review.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, School of Medicine, University of Louisville, Louisville, KY, USA

    Michael P. Flaherty

  2. Department of Cardiovascular and Thoracic Surgery, University of Louisville, School of Medicine and Jewish Hospital Rudd Heart and Lung Institute, Rudd Heart and Lung Center, 201 Abraham Flexner Way Suite 1200, Louisville, KY, 40202, USA

    Kendra J. Grubb

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  1. Michael P. Flaherty
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Correspondence to Kendra J. Grubb.

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Flaherty, M.P., Grubb, K.J. Transcatheter Aortic Valve Replacement: Focus on Sex-Related Differences in Outcomes. Am J Cardiovasc Drugs 15, 95–101 (2015). https://doi.org/10.1007/s40256-015-0110-y

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  • DOI: https://doi.org/10.1007/s40256-015-0110-y

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