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Potassium tert-Butanolate promoted reaction of benzaldehydes and indoles: a new strategy for synthesis of bis(indolyl)arylmethanes

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Abstract

t-BuOK-promoted synthesis of bis(indolyl)arylmethanes from aromatic aldehydes and indoles is achieved. Substrates bearing different functional groups, especially groups which are sensitive to acidic media, are well tole-rated under the optimal condition, making this reaction particularly attractive for expanding the scope of the present protocols that provides bis(1H-indol-3-yl)arylmethanes.

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Authors and Affiliations

  1. Key Laboratory of Drug-targeting, Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China

    Chong Jiang, Jue Li, Guanghui Lü, Yang Zheng, Xinling Yu, Songyang Lü, Li Hai & Yong Wu

  2. Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, P. R. China

    Guanghui Lü

Authors
  1. Chong Jiang
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  2. Jue Li
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  3. Guanghui Lü
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  4. Yang Zheng
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  5. Xinling Yu
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  6. Songyang Lü
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  7. Li Hai
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  8. Yong Wu
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Corresponding author

Correspondence to Yong Wu.

Additional information

Supported by the National Natural Science Foundation of China(Nos.81373259, 81573286).

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Jiang, C., Li, J., Lü, G. et al. Potassium tert-Butanolate promoted reaction of benzaldehydes and indoles: a new strategy for synthesis of bis(indolyl)arylmethanes. Chem. Res. Chin. Univ. 33, 200–205 (2017). https://doi.org/10.1007/s40242-017-6382-9

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  • DOI: https://doi.org/10.1007/s40242-017-6382-9

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