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Synthesis and characterization of novel N-phenylacetamide bearing 1,2,4-triazole derivatives as potential antimicrobial agents

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Abstract

A new series of 1-substituted phenyl-2-(1H-1,2,4-triazol-1-yl)ethanone derivatives 3a―3f was synthe-sized and their structures were characterized by IR, 1H NMR, 13C NMR and HRMS spectral analysis. Antimicrobial activities of the derivatives were measured against both bacteria and fungi. In vitro antifungal evaluation showed that five compounds(3b―3f) had growth inhibitory effects on the tested fungus, and three of them(3b, 3c and 3e) showed special efficacy against Gram negative bacteria.

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Authors and Affiliations

  1. School of Life Sciences, Jilin University, Changchun, 130012, P. R. China

    Bochao Li, Yang Xiao & Feng Lin

  2. School of Nursing, Northeast Normal University, Changchun, 130117, P. R. China

    Xinrui Lin

  3. School of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Yumin Zhang & Dawei Zhang

Authors
  1. Bochao Li
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  2. Xinrui Lin
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  3. Yumin Zhang
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  4. Dawei Zhang
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  5. Yang Xiao
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  6. Feng Lin
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Corresponding author

Correspondence to Feng Lin.

Additional information

Supported by the Fund for the 12th Five-year Scientific and Technical Research Plan of Department of Education of Jilin Province, China(No.2014B002).

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Li, B., Lin, X., Zhang, Y. et al. Synthesis and characterization of novel N-phenylacetamide bearing 1,2,4-triazole derivatives as potential antimicrobial agents. Chem. Res. Chin. Univ. 33, 70–73 (2017). https://doi.org/10.1007/s40242-017-6327-3

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  • DOI: https://doi.org/10.1007/s40242-017-6327-3

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