Abstract
We described a novel approach for survivin siRNA cellular delivery via a cationic liposome incorporating fatty acid-modified polyethylenimine. A linoleic acid derivative of branched polyethylenimine(PEI, M w=25 kDa), PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEI-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently compared with PEI-25kDa.
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Supported by the Open Project of the State Key Laboratory of Long-acting and Targeting Drug Delivery Technologies, China.
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Yang, S., Guo, Z., Yang, X. et al. Enhanced survivin siRNA delivery using cationic liposome incorporating fatty acid-modified polyethylenimine. Chem. Res. Chin. Univ. 31, 401–405 (2015). https://doi.org/10.1007/s40242-015-5060-z
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DOI: https://doi.org/10.1007/s40242-015-5060-z