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Pediatric Regional Anesthesia: an Update

  • Pediatric Anesthesia (J Lerman, Section Editor)
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Abstract

The Purpose of Review

The purpose of this study was to review the recent literature describing techniques, outcomes, and complications in pediatric regional anesthesia primarily among neonates and infants.

Recent Findings

Regional anesthetic techniques can be safely performed in anesthetized children, and is so widespread, that it has become accepted as standard of practice. Spinal anesthesia in the neonate requires a larger dose of local anesthetic than in adults, yet has a shorter duration of action. Neuraxial technique combined with sedation or light general anesthesia is commonly used for hernia repairs. In preterm and ex-preterm infants, awake regional techniques are reasonable alternatives. Neuraxial catheters can deliver local anesthetics and opioids both intraoperatively and postoperatively for effective pain control in all age groups including neonates. Ultrasound guidance has rapidly become the norm to ensure successful peripheral nerve blocks and abdominal wall blocks with the least amounts of local anesthetics. The dose of local anesthetic should be adjusted for each patient based on the recommended range.

Summary

Regional anesthesia has shown to be safe and is being increasingly practiced. But safety should be the priority and adequate precautions should be taken to reduce potential complications.

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Notes

  1. Abstract #1697 at the 16th World Congress of Anaesthesiologists, 2016, Hong Kong.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. •• Taenzer AH, Walker BJ, Bosenberg AT, Martin L, Suresh S, Polaner DM, et al. Asleep versus awake: does it matter?: pediatric regional block complications by patient state: a report from the Pediatric Regional Anesthesia Network. Reg Anesth Pain Med. 2014;39(4):279–83. doi:10.1097/AAP.0000000000000102. Prospective evidence for the safety of regional blocks performed in anesthetized patients reported for the first time

    Article  PubMed  Google Scholar 

  2. • Suresh S, Schaldenbrand K, Wallis B, De Oliveira GS, Jr. Regional anaesthesia to improve pain outcomes in paediatric surgical patients: a qualitative systematic review of randomized controlled trials. Br J Anaesth. 2014;113(3):375–90. doi:10.1093/bja/aeu156. A literature review looking for the evidence for improved postoperative pain outcomes after regional anesthetic techniques in children

    Article  CAS  PubMed  Google Scholar 

  3. Polaner DM, Taenzer AH, Walker BJ, Bosenberg A, Krane EJ, Suresh S, et al. Pediatric Regional Anesthesia Network (PRAN): a multi-institutional study of the use and incidence of complications of pediatric regional anesthesia. Anesth Analg. 2012;115(6):1353–64. doi:10.1213/ANE.0b013e31825d9f4b.

    Article  CAS  PubMed  Google Scholar 

  4. Aggarwal A, Sahni D, Kaur H, Batra YK, Sondekoppam VR. The caudal space in fetuses: an anatomical study. J Anesth. 2012;26(2):206–12. doi:10.1007/s00540-011-1271-8.

    Article  PubMed  Google Scholar 

  5. Koo BN, Hong JY, Kil HK. Spread of ropivacaine by a weight-based formula in a pediatric caudal block: a fluoroscopic examination. Acta Anaesthesiol Scand. 2010;54(5):562–5. doi:10.1111/j.1399-6576.2010.02224.x.

    Article  CAS  PubMed  Google Scholar 

  6. Lundblad M, Lonnqvist PA, Eksborg S, Marhofer P. Segmental distribution of high-volume caudal anesthesia in neonates, infants, and toddlers as assessed by ultrasonography. Paediatr Anaesth. 2011;21(2):121–7. doi:10.1111/j.1460-9592.2010.03485.x.

    Article  PubMed  Google Scholar 

  7. Triffterer L, Machata AM, Latzke D, Willschke H, Rebhandl W, Kimberger O, et al. Ultrasound assessment of cranial spread during caudal blockade in children: effect of the speed of injection of local anaesthetics. Br J Anaesth. 2012;108(4):670–4. doi:10.1093/bja/aer502.

    Article  CAS  PubMed  Google Scholar 

  8. Brenner L, Marhofer P, Kettner SC, Willschke H, Machata AM, Al-Zoraigi U, et al. Ultrasound assessment of cranial spread during caudal blockade in children: the effect of different volumes of local anaesthetics. Br J Anaesth. 2011;107(2):229–35. doi:10.1093/bja/aer128.

    Article  CAS  PubMed  Google Scholar 

  9. Thomas ML, Roebuck D, Yule C, Howard RF. The effect of volume of local anesthetic on the anatomic spread of caudal block in children aged 1–7 years. Paediatr Anaesth. 2010;20(11):1017–21. doi:10.1111/j.1460-9592.2010.03422.x.

    Article  CAS  PubMed  Google Scholar 

  10. Lundblad M, Eksborg S, Lonnqvist PA. Secondary spread of caudal block as assessed by ultrasonography. Br J Anaesth. 2012;108(4):675–81. doi:10.1093/bja/aer513.

    Article  CAS  PubMed  Google Scholar 

  11. Mueller CM, Sinclair TJ, Stevens M, Esquivel M, Gordon N. Regional block via continuous caudal infusion as sole anesthetic for inguinal hernia repair in conscious neonates. Pediatr Surg Int. 2016; doi:10.1007/s00383-016-4027-6.

    Article  PubMed  Google Scholar 

  12. Hoelzle M, Weiss M, Dillier C, Gerber A. Comparison of awake spinal with awake caudal anesthesia in preterm and ex-preterm infants for herniotomy. Paediatr Anaesth. 2010;20(7):620–4. doi:10.1111/j.1460-9592.2010.03316.x.

    Article  PubMed  Google Scholar 

  13. Marhofer P, Keplinger M, Klug W, Metzelder ML. Awake caudals and epidurals should be used more frequently in neonates and infants. Paediatr Anaesth. 2015;25(1):93–9. doi:10.1111/pan.12543.

    Article  PubMed  Google Scholar 

  14. Meyer MJ, Krane EJ, Goldschneider KR, Klein NJ. Case report: neurological complications associated with epidural analgesia in children: a report of 4 cases of ambiguous etiologies. Anesth Analg. 2012;115(6):1365–70. doi:10.1213/ANE.0b013e31826918b6.

    Article  PubMed  Google Scholar 

  15. • Long JB, Joselyn AS, Bhalla T, Tobias JD, De Oliveira Jr GS, Suresh S, et al. The use of neuraxial catheters for postoperative analgesia in neonates: a multicenter safety analysis from the Pediatric Regional Anesthesia Network. Anesth Analg. 2016;122(6):1965–70. doi:10.1213/ANE.0000000000001322. A study reporting on large number of neuraxial catheter techniques in neonates

    Article  CAS  PubMed  Google Scholar 

  16. Allison CE, Aronson DC, Geukers VG, van den Berg R, Schlack WS, Hollmann MW. Paraplegia after thoracotomy under combined general and epidural anesthesia in a child. Paediatr Anaesth. 2008;18(6):539–42. doi:10.1111/j.1460-9592.2008.02590.x.

    Article  CAS  PubMed  Google Scholar 

  17. Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA. 1983;249(13):1743–5.

    Article  CAS  Google Scholar 

  18. Bosenberg A, Flick RP. Regional anesthesia in neonates and infants. Clin Perinatol. 2013;40(3):525–38. doi:10.1016/j.clp.2013.05.011.

    Article  PubMed  Google Scholar 

  19. Moriarty A. Pediatric epidural analgesia (PEA). Paediatr Anaesth. 2012;22(1):51–5. doi:10.1111/j.1460-9592.2011.03731.x.

    Article  PubMed  Google Scholar 

  20. Franklin AD, Hughes EM. Fluoroscopically guided tunneled trans-caudal epidural catheter technique for opioid-free neonatal epidural analgesia. J Anesth. 2016;30(3):493–7. doi:10.1007/s00540-016-2147-8.

    Article  PubMed  Google Scholar 

  21. Mixa V, Nedomova B, Berka I. Continuous epidural analgesia, a new prospect in analgesia of newborns. Bratisl Lek Listy. 2015;116(9):571–3.

    CAS  PubMed  Google Scholar 

  22. Farid IS, Kendrick EJ, Adamczyk MJ, Lukas NR, Massanyi EZ. Perioperative analgesic management of newborn bladder exstrophy repair using a directly placed tunneled epidural catheter with 0.1% ropivacaine. A A Case Rep. 2015;5(7):112–4. doi:10.1213/XAA.0000000000000191.

    Article  PubMed  Google Scholar 

  23. Krane EJ, Dalens BJ, Murat I, Murrell D. The safety of epidurals placed during general anesthesia. Reg Anesth Pain Med. 1998;23(5):433–8.

    Article  CAS  Google Scholar 

  24. Johr M. Regional anaesthesia in neonates, infants and children: an educational review. Eur J Anaesthesiol. 2015;32(5):289–97. doi:10.1097/EJA.0000000000000239.

    Article  CAS  PubMed  Google Scholar 

  25. Calder A, Bell GT, Andersson M, Thomson AH, Watson DG, Morton NS. Pharmacokinetic profiles of epidural bupivacaine and ropivacaine following single-shot and continuous epidural use in young infants. Paediatr Anaesth. 2012;22(5):430–7. doi:10.1111/j.1460-9592.2011.03771.x.

    Article  PubMed  Google Scholar 

  26. Lonnqvist PA. Regional anaesthesia and analgesia in the neonate. Best Pract Res Clin Anaesthesiol. 2010;24(3):309–21.

    Article  Google Scholar 

  27. Bosenberg AT, Thomas J, Cronje L, Lopez T, Crean PM, Gustafsson U, et al. Pharmacokinetics and efficacy of ropivacaine for continuous epidural infusion in neonates and infants. Paediatr Anaesth. 2005;15(9):739–49. doi:10.1111/j.1460-9592.2004.01550.x.

    Article  PubMed  Google Scholar 

  28. Aarons L, Sadler B, Pitsiu M, Sjovall J, Henriksson J, Molnar V. Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′-pipecoloxylidide from pooled data in neonates, infants, and children. Br J Anaesth. 2011;107(3):409–24. doi:10.1093/bja/aer154.

    Article  CAS  PubMed  Google Scholar 

  29. Veneziano G, Iliev P, Tripi J, Martin D, Aldrink J, Bhalla T, et al. Continuous chloroprocaine infusion for thoracic and caudal epidurals as a postoperative analgesia modality in neonates, infants, and children. Paediatr Anaesth. 2016;26(1):84–91. doi:10.1111/pan.12807.

    Article  PubMed  Google Scholar 

  30. Muhly WT, Gurnaney HG, Kraemer FW, Ganesh A, Maxwell LG. A retrospective comparison of ropivacaine and 2-chloroprocaine continuous thoracic epidural analgesia for management of postthoracotomy pain in infants. Paediatr Anaesth. 2015;25(11):1162–7. doi:10.1111/pan.12745.

    Article  PubMed  Google Scholar 

  31. Ross EL, Reiter PD, Murphy ME, Bielsky AR. Evaluation of prolonged epidural chloroprocaine for postoperative analgesia in infants. J Clin Anesth. 2015;27(6):463–9. doi:10.1016/j.jclinane.2015.05.022.

    Article  CAS  PubMed  Google Scholar 

  32. Cucchiaro G, Adzick SN, Rose JB, Maxwell L, Watcha M. A comparison of epidural bupivacaine-fentanyl and bupivacaine-clonidine in children undergoing the Nuss procedure. Anesth Analg. 2006;103(2):322–327, table of contents. doi: 10.1213/01.ane.0000221047.68114.ad.

    Article  CAS  PubMed  Google Scholar 

  33. Shenkman Z, Hoppenstein D, Erez I, Dolfin T, Freud E. Continuous lumbar/thoracic epidural analgesia in low-weight paediatric surgical patients: practical aspects and pitfalls. Pediatr Surg Int. 2009;25(7):623–34. doi:10.1007/s00383-009-2386-y.

    Article  PubMed  Google Scholar 

  34. Raghavan M, Montgomerie J. Anesthetic management of gastrochisis—a review of our practice over the past 5 years. Paediatr Anaesth. 2008;18(11):1055–9. doi:10.1111/j.1460-9592.2008.02762.x.

    Article  PubMed  Google Scholar 

  35. Goeller JK, Bhalla T, Tobias JD. Combined use of neuraxial and general anesthesia during major abdominal procedures in neonates and infants. Paediatr Anaesth. 2014;24(6):553–60. doi:10.1111/pan.12384.

    Article  PubMed  Google Scholar 

  36. Abajian JC, Mellish RW, Browne AF, Perkins FM, Lambert DH, Mazuzan Jr JE. Spinal anesthesia for surgery in the high-risk infant. Anesth Analg. 1984;63(3):359–62.

    Article  CAS  Google Scholar 

  37. Davidson AJ, Disma N, de Graaff JC, Withington DE, Dorris L, Bell G, et al. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet. 2016;387(10015):239–50. doi:10.1016/S0140-6736(15)00608-X.

    Article  PubMed  Google Scholar 

  38. Yahalom B, Athiraman U, Soriano SG, Zurakowski D, Carpino EA, Corfas G, et al. Spinal anesthesia in infant rats: development of a model and assessment of neurologic outcomes. Anesthesiology. 2011;114(6):1325–35. doi:10.1097/ALN.0b013e31821b5729.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Hamurtekin E, Fitzsimmons BL, Shubayev VI, Grafe MR, Deumens R, Yaksh TL, et al. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 2013;119(1):142–55. doi:10.1097/ALN.0b013e31828fc7e7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. •• Williams RK, Black IH, Howard DB, Adams DC, Mathews DM, Friend AF, et al. Cognitive outcome after spinal anesthesia and surgery during infancy. Anesth Analg. 2014;119(3):651–60. doi:10.1213/ANE.0000000000000288. A retrospective observational study looking at a relationship between spinal anesthetic exposure in infancy and the likelihood of very poor academic achievement

    Article  CAS  PubMed  Google Scholar 

  41. Bhalotra AR. Should awake caudals and epidurals be used more frequently in neonates and infants? Paediatr Anaesth. 2015;25(12):1299. doi:10.1111/pan.12744.

    Article  PubMed  Google Scholar 

  42. Hermanns H, Stevens MF, Werdehausen R, Braun S, Lipfert P, Jetzek-Zader M. Sedation during spinal anaesthesia in infants. Br J Anaesth. 2006;97(3):380–4. doi:10.1093/bja/ael156.

    Article  CAS  PubMed  Google Scholar 

  43. Oncel S, Gunlemez A, Anik Y, Alvur M. Positioning of infants in the neonatal intensive care unit for lumbar puncture as determined by bedside ultrasonography. Arch Dis Child Fetal Neonatal Ed. 2013;98(2):F133–5. doi:10.1136/archdischild-2011-301475.

    Article  PubMed  Google Scholar 

  44. Lo MD, Parisi MT, Brown JC, Klein EJ. Sitting or tilt position for infant lumbar puncture does not increase ultrasound measurements of lumbar subarachnoid space width. Pediatr Emerg Care. 2013;29(5):588–91. doi:10.1097/PEC.0b013e31828e630d.

    Article  PubMed  Google Scholar 

  45. van Schoor A, Bosman MC, Bosenberg AT. The value of Tuffier’s line for neonatal neuraxial procedures. Clin Anat. 2014;27(3):370–5. doi:10.1002/ca.22218.

    Article  PubMed  Google Scholar 

  46. Ferayorni A, Yniguez R, Bryson M, Bulloch B. Needle-free jet injection of lidocaine for local anesthesia during lumbar puncture: a randomized controlled trial. Pediatr Emerg Care. 2012;28(7):687–90. doi:10.1097/PEC.0b013e31825d210b.

    Article  PubMed  Google Scholar 

  47. Frawley G, Smith KR, Ingelmo P. Relative potencies of bupivacaine, levobupivacaine, and ropivacaine for neonatal spinal anaesthesia. Br J Anaesth. 2009;103(5):731–8. doi:10.1093/bja/aep259.

    Article  CAS  PubMed  Google Scholar 

  48. Kokki H, Ylonen P, Laisalmi M, Heikkinen M, Reinikainen M. Isobaric ropivacaine 5 mg/ml for spinal anesthesia in children. Anesth Analg. 2005;100(1):66–70. doi:10.1213/01.ANE.0000140246.78944.A5.

    Article  CAS  PubMed  Google Scholar 

  49. • Frawley G, Bell G, Disma N, Withington DE, de Graaff JC, Morton NS, et al. Predictors of failure of awake regional anesthesia for neonatal hernia repair: data from the general anesthesia compared to spinal anesthesia study—comparing apnea and neurodevelopmental outcomes. Anesthesiology. 2015;123(1):55–65. doi:10.1097/ALN.0000000000000708. A prospective randomized international study reporting on awake regional techniques in neonates

    Article  PubMed  PubMed Central  Google Scholar 

  50. Fosel T, Wilhelm W, Gruness V, Molter G. Spinal anesthesia in infancy using bupivacaine 0.5%. The effect of an adrenaline addition on duration and hemodynamics. Anaesthesist. 1994;43(1):26–9.

    Article  CAS  Google Scholar 

  51. Kokki H. Spinal blocks. Paediatr Anaesth. 2012;22(1):56–64. doi:10.1111/j.1460-9592.2011.03693.x.

    Article  PubMed  Google Scholar 

  52. Marhofer P, Lonnqvist PA. The use of ultrasound-guided regional anaesthetic techniques in neonates and young infants. Acta Anaesthesiol Scand. 2014;58(9):1049–60. doi:10.1111/aas.12372.

    Article  CAS  PubMed  Google Scholar 

  53. Gurnaney HG, Maxwell LG, Kraemer FW, Goebel T, Nance ML, Ganesh A. Prospective randomized observer-blinded study comparing the analgesic efficacy of ultrasound-guided rectus sheath block and local anaesthetic infiltration for umbilical hernia repair. Br J Anaesth. 2011;107(5):790–5. doi:10.1093/bja/aer263.

    Article  CAS  PubMed  Google Scholar 

  54. Lissauer J, Mancuso K, Merritt C, Prabhakar A, Kaye AD, Urman RD. Evolution of the transversus abdominis plane block and its role in postoperative analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(2):117–26. doi:10.1016/j.bpa.2014.04.001.

    Article  PubMed  Google Scholar 

  55. Mai CL, Young MJ, Quraishi SA. Clinical implications of the transversus abdominis plane block in pediatric anesthesia. Paediatr Anaesth. 2012;22(9):831–40. doi:10.1111/j.1460-9592.2012.03916.x.

    Article  PubMed  Google Scholar 

  56. Long JB, Birmingham PK, De Oliveira GS, Jr Schaldenbrand KM, Suresh S. Transversus abdominis plane block in children: a multicenter safety analysis of 1994 cases from the PRAN (Pediatric Regional Anesthesia Network) database. Anesth Analg 2014;119(2):395–399. doi:10.1213/ANE.0000000000000284.

  57. Fredrickson MJ, Paine C, Hamill J. Improved analgesia with the ilioinguinal block compared to the transversus abdominis plane block after pediatric inguinal surgery: a prospective randomized trial. Paediatr Anaesth. 2010;20(11):1022–7. doi:10.1111/j.1460-9592.2010.03432.x.

    Article  PubMed  Google Scholar 

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Correspondence to Madhankumar Sathyamoorthy.

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This article is part of the Topical Collection on Pediatric Anesthesia

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Sathyamoorthy, M. Pediatric Regional Anesthesia: an Update. Curr Anesthesiol Rep 7, 150–155 (2017). https://doi.org/10.1007/s40140-017-0217-6

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