Generation of Lung Epithelium from Pluripotent Stem Cells
- Amy P. WongAffiliated withProgram in Developmental & Stem Cell Biology, Hospital for Sick Children
- , Janet RossantAffiliated withProgram in Developmental & Stem Cell Biology, Hospital for Sick ChildrenDepartment of Molecular Genetics, University of TorontoHospital for Sick Children Email author
The understanding of key processes and signaling mechanisms in lung development has been mainly demonstrated through gain and loss of function studies in mice, while human lung development remains largely unexplored due to inaccessibility. Several recent reports have exploited the identification of key signaling mechanisms that regulate lineage commitment and restriction in mouse lung development, to direct differentiation of both mouse and human pluripotent stem cells towards lung epithelial cells. In this review, we discuss the recent advances in the generation of respiratory epithelia from pluripotent stem cells and the potential of these engineered cells for novel scientific discoveries in lung diseases and future translation into regenerative therapies.
KeywordsLung Embryonic stem cells Induced pluripotent stem cells Cystic fibrosis Lung development Airway epithelium Pathobiology
- Generation of Lung Epithelium from Pluripotent Stem Cells
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Current Pathobiology Reports
Volume 1, Issue 2 , pp 137-145
- Cover Date
- Online ISSN
- Current Science Inc.
- Additional Links
- Embryonic stem cells
- Induced pluripotent stem cells
- Cystic fibrosis
- Lung development
- Airway epithelium
- Author Affiliations
- 1. Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada
- 2. Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada
- 3. Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada