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Cost-Efficient Workup and Management of Patients with Chronic Rhinosinusitis: Challenges and Unmet Needs

  • Rhinology (R. Orlandi, Section Editor)
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Abstract

Chronic rhinosinusitis (CRS) is a common disease, estimated to occur in 12–16 % of the United States population. This prevalence creates a significant health burden with an estimated 15 million ambulatory visits for the condition annually. Consequently, practice guidelines have been designed to assist both the primary care provider and specialist in establishing a CRS diagnosis and prescribing effective treatment for CRS. The guidelines for CRS diagnosis have evolved since the United States Rhinosinusitis Task Force first published its symptom-based guidelines in 1997. Contemporary practice guidelines still require 12 weeks of appropriate symptoms, but now include corroboration of objective sinonasal inflammation demonstrated on physical exam, imaging, or endoscopy to arrive at a CRS diagnosis. While these diagnostic criteria are seemingly straightforward and are regarded as the gold standard for the diagnosis, the appropriate timing of imaging and endoscopy remain unspecified and continue to present challenges for both primary care and specialty providers. These considerations have to be measured by the direct and indirect costs of the diagnostic workup including office visits, CT scanning, endoscopy, as well as the potential for overuse of treatment modalities such as antibiotics and steroid medications. The goal of this review is to update the primary care provider and otolaryngologist on current evidence regarding the diagnosis and treatment of CRS, including the costs and timing of endoscopy and imaging.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. •• Fokkens WJ, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012; 50(1): 1–12. European consensus guidelines for the workup and treatment of acute and chronic sinusitis with and without polyps. A comprehensive resource.

  2. Bhattacharyya N. Incremental health care utilization and expenditures for chronic rhinosinusitis in the United States. Ann Otol Rhinol Laryngol. 2011;120(7):423–7.

    Article  PubMed  Google Scholar 

  3. Blackwell DL, Collins JG, Coles R. Summary health statistics for U.S. adults: National Health Interview Survey, 1997. Vital Health Stat. 2002;10(205):1–109.

    Google Scholar 

  4. Amine M, et al. Outcomes of endoscopy and computed tomography in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013; 3(1): 73–9. Retrospective review demonstrating that number of symptoms correlated strongly with disease, and that incorporating number of symptoms was able to improve the sensitivity of nasal endoscopy and reduce the utilization of CT.

  5. Lanza DC, Kennedy DW. Adult rhinosinusitis defined. Otolaryngol Head Neck Surg. 1997;117(3 Pt 2):S1–7.

    Article  CAS  PubMed  Google Scholar 

  6. Bhattacharyya N. Clinical and symptom criteria for the accurate diagnosis of chronic rhinosinusitis. Laryngoscope. 2006;116(7 Pt 2 Suppl 110):1–22.

    Article  PubMed  Google Scholar 

  7. Hwang PH, et al. Radiologic correlates of symptom-based diagnostic criteria for chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2003;128(4):489–96.

    Article  PubMed  Google Scholar 

  8. Rosenfeld RM. Clinical practice guideline on adult sinusitis. Otolaryngol Head Neck Surg. 2007;137(3):365–77.

    Article  PubMed  Google Scholar 

  9. Tan BK, et al. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2013; 131(5): 1350–60. Patients with CRS have a higher incidence of anxiety, headaches, GERD, OSA, and URI, resulting in higher health care use, including antibiotic and corticosteroid use.

  10. Bhattacharyya N, Lee LN. Evaluating the diagnosis of chronic rhinosinusitis based on clinical guidelines and endoscopy. Otolaryngol Head Neck Surg. 2010;143(1):147–51.

    Article  PubMed  Google Scholar 

  11. Ferguson BJ, et al. Prospective observational study of chronic rhinosinusitis: environmental triggers and antibiotic implications. Clin Infect Dis. 2012;54(1):62–8.

    Article  PubMed  Google Scholar 

  12. Darrat I, et al. A study of adherence to the AAO-HNS “Clinical Practice Guideline: adult Sinusitis”. Ear Nose Throat J. 2014;93(8):338–52.

    PubMed  Google Scholar 

  13. Smith SS, et al. National burden of antibiotic use for adult rhinosinusitis. J Allergy Clin Immunol. 2013; 132(5): 1230–2. Thorough analysis of DHHS data to help understand the antibiotic prescribing patterns in ARS and CRS.

  14. C.f.D.C.a. Prevention. Antibiotic Resistance Threats in the United States, 2013. 2013. http://www.cdc.gov/drugresistance/threat-report-2013/index.html. Accessed 1 Nov 2014.

  15. Dubin MG, et al. American Rhinologic Society member survey on “maximal medical therapy” for chronic rhinosinusitis. Am J Rhinol. 2007;21(4):483–8.

    Article  PubMed  Google Scholar 

  16. Lund VJ. Maximal medical therapy for chronic rhinosinusitis. Otolaryngol Clin North Am. 2005;38(6):1301–10.

    Article  PubMed  Google Scholar 

  17. Sylvester DC, Carr S, Nix P. Maximal medical therapy for chronic rhinosinusitis: a survey of otolaryngology consultants in the United Kingdom. Int Forum Allergy Rhinol. 2013; 3(2): 129–32. UK survey demonstrating that although MMT for CRS typically included antibiotics, nasal steroids and saline irrigations, it still greatly varies between providers.

  18. Rudmik L et al. Productivity costs in patients with refractory chronic rhinosinusitis. Laryngoscope. 2014; 124(9): 2007–12. Analyses of the direct and indirect costs of CRS demonstrate an annual cost of approximately $10,000 per patient with refractory disease.

  19. Stankiewicz JA, Chow JM. Cost analysis in the diagnosis of chronic rhinosinusitis. Am J Rhinol. 2003;17(3):139–42.

    PubMed  Google Scholar 

  20. Benninger MS, et al. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129(3 Suppl):S1–32.

    Article  PubMed  Google Scholar 

  21. Hsueh WD, et al. Identifying clinical symptoms for improving the symptomatic diagnosis of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013; 3(4): 307–14. Hyposmia was found to positively predict CRS, while facial pain of pulsating quality, headaches, and photophobia correlated negatively.

  22. Tan BK, et al. Effect of symptom-based risk stratification on the costs of managing patients with chronic rhinosinusitis symptoms. Int Forum Allergy Rhinol. 2013;3(11):933–40.

    Article  PubMed  Google Scholar 

  23. Leung RM, et al. Primary care and upfront computed tomography scanning in the diagnosis of chronic rhinosinusitis: a cost-based decision analysis. Laryngoscope. 2014; 124(1): 12–8. Multiscenario analysis of cost savings from up front CT scanning demonstrated cost savings of approximately $300 whether or not Point of Care CT was available.

  24. Stankiewicz JA, Chow JM. Nasal endoscopy and the definition and diagnosis of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2002;126(6):623–7.

    Article  PubMed  Google Scholar 

  25. Wuister AM, et al. Nasal endoscopy is recommended for diagnosing adults with chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2014;150(3):359–64.

    Article  PubMed  Google Scholar 

  26. Agius AM. Long-term follow-up of patients with facial pain in chronic rhinosinusitis—correlation with nasal endoscopy and CT. Rhinology. 2010;48(1):65–70.

    CAS  PubMed  Google Scholar 

  27. Thunberg U, et al. Anterior rhinoscopy and middle meatal culture in acute rhinosinusitis. J Laryngol Otol. 2013;127(11):1088–92.

    Article  CAS  PubMed  Google Scholar 

  28. Raithatha R, et al. Interrater agreement of nasal endoscopy for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2012;2(2):144–50.

    Article  PubMed  Google Scholar 

  29. Cornelius RS, et al. ACR appropriateness criteria sinonasal disease. J Am Coll Radiol. 2013; 10(4): 241–6. Current American College of Radiology modality criteria for ARS and CRS. CT scanning is noted to be the most effective modality.

  30. Aalokken TM, et al. Conventional sinus radiography compared with CT in the diagnosis of acute sinusitis. Dentomaxillofac Radiol. 2003;32(1):60–2.

    Article  CAS  PubMed  Google Scholar 

  31. Desrosiers M, et al. Canadian clinical practice guidelines for acute and chronic rhinosinusitis. Allergy Asthma Clin Immunol. 2011;7(1):2.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Brenner DJ, Hall EJ. Computed tomography–an increasing source of radiation exposure. N Engl J Med. 2007;357(22):2277–84.

    Article  CAS  PubMed  Google Scholar 

  33. Leung R, et al. Advancements in computed tomography management of chronic rhinosinusitis. Am J Rhinol Allergy. 2011;25(5):299–302.

    Article  PubMed  Google Scholar 

  34. Stewart AE, et al. Variability of radiation exposure with in-office sinus computed tomography examinations. Int Forum Allergy Rhinol. 2011;1(4):313–8.

    Article  PubMed  Google Scholar 

  35. Daramola OO, et al. Patient knowledge and perception of computed tomography scan in the management of chronic rhinosinusitis symptoms. Laryngoscope. 2014;. doi:10.1002/lary.24992.

    PubMed  Google Scholar 

  36. Dalgorf DM, et al. Image-guided surgery influences perioperative morbidity from endoscopic sinus surgery: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2013;149(1):17–29.

    Article  PubMed  Google Scholar 

  37. Baguley C, et al. The fate of chronic rhinosinusitis sufferers after maximal medical therapy. Int Forum Allergy Rhinol. 2014;4(7):525–32.

    Article  PubMed  Google Scholar 

  38. Campbell PD Jr, Zinreich SJ, Aygun N. Imaging of the paranasal sinuses and in-office CT. Otolaryngol Clin North Am. 2009;42(5):753–64 vii.

    Article  PubMed  Google Scholar 

  39. Leung R, et al. Upfront computed tomography scanning is more cost-beneficial than empiric medical therapy in the initial management of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2011;1(6):471–80.

    Article  PubMed  Google Scholar 

  40. Kuijper EJ, et al. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect. 2006;12(Suppl 6):2–18.

    Article  CAS  PubMed  Google Scholar 

  41. Wong GK, Poon WS, Chiu KH. Steroid-induced avascular necrosis of the hip in neurosurgical patients: epidemiological study. ANZ J Surg. 2005;75(6):409–10.

    Article  PubMed  Google Scholar 

  42. van Staa TP, et al. Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology. 2000;39(12):1383–9.

    Article  PubMed  Google Scholar 

  43. De Vries F, et al. Fracture risk with intermittent high-dose oral glucocorticoid therapy. Arthritis Rheum. 2007;56(1):208–14.

    Article  PubMed  Google Scholar 

  44. The Royal College of Surgeons. 2013 Commissioning guide: rhinosinusitis. 2013. https://www.rcseng.ac.uk/healthcare-bodies/docs/published-guides/rhinosinusitus. Accessed 27 Feb 2015.

  45. Schreiber CP, et al. Prevalence of migraine in patients with a history of self-reported or physician-diagnosed “sinus” headache. Arch Intern Med. 2004;164(16):1769–72.

    Article  PubMed  Google Scholar 

  46. Kari E, DelGaudio JM. Treatment of sinus headache as migraine: the diagnostic utility of triptans. Laryngoscope. 2008;118(12):2235–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the NIH Grants K23DC012067 and the Triological Society/American College of Surgeons.

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Correspondence to Bruce K. Tan.

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This article is part of the Topical Collection on Rhinology.

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Lobo, B.C., Ting, J.Y. & Tan, B.K. Cost-Efficient Workup and Management of Patients with Chronic Rhinosinusitis: Challenges and Unmet Needs. Curr Otorhinolaryngol Rep 3, 94–100 (2015). https://doi.org/10.1007/s40136-015-0078-9

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  • DOI: https://doi.org/10.1007/s40136-015-0078-9

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