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Sustained release coating of ibuprofen pellets at Wurster fluidization: statistical approach

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Abstract

The Wurster fluidization coating is recognized in many pharmaceutical industries for its precise film coating onto particulate materials such as pellets, granules, and powders. The current work focused on some process variables to study sustained release behavior of ibuprofen pellets at a lab-scale Wurster fluidized bed coater. Applying design of experiment, the effect of mean pellets size (d p ), air flow rate (Q a ), coating solution flow rate (Q s ), and drying time duration (t d ) were investigated statistically on the mean dissolution time (MDT) of ibuprofen pellets. Results in analysis of variance illustrated that a decrease in d p make rising of MDT due to decreasing the ibuprofen diffusivity in the media owing to trapping role of ethyl cellulose. It was also found increasing of Q s resulted in extending of MDT due as the coating solution deposited on the pellets surface was increased. While the t d did not play an important role on the MDT, the MDT was increased by Q a because of pellets circulation within the bed.

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Abbreviations

d p,avg :

Average particle size (µm)

MDT:

Mean dissolution time (min)

Q a :

Air flow (l/min)

Q s :

Coating solution flow (l/hr)

RPM:

Rotation per minute

t d :

Drying time duration (min)

t :

Time (min)

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Acknowledgement

All authors (H. Sedighikamal, R. Zarghami, P. Khadiv-Parsi, and N. Mostoufi) declare that they have no conflict of interest. This article does not contain any studies with human and animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Division of Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11155, 4563, Tehran, Iran

    Hossein Sedighikamal, Reza Zarghami, Parissa Khadiv-Parsi & Navid Mostoufi

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  1. Hossein Sedighikamal
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  2. Reza Zarghami
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  3. Parissa Khadiv-Parsi
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  4. Navid Mostoufi
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Correspondence to Hossein Sedighikamal.

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Sedighikamal, H., Zarghami, R., Khadiv-Parsi, P. et al. Sustained release coating of ibuprofen pellets at Wurster fluidization: statistical approach. Journal of Pharmaceutical Investigation 45, 341–347 (2015). https://doi.org/10.1007/s40005-015-0177-0

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  • DOI: https://doi.org/10.1007/s40005-015-0177-0

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