Skip to main content
SpringerLink
Log in

Fabrication and characterization of liquisolid compacts of Embelin for dissolution enhancement

  • Research Article
  • Published:
Journal of Pharmaceutical Investigation Aims and scope Submit manuscript

Abstract

In the present investigation, an attempt was made to improve the dissolution properties of water insoluble herbal active ingredient, Embelin (EBN) by utilizing liquisolid technique, which might offer improved bioavailability. The compacts were prepared using Capryol 90 as non-volatile solvent, Neusilin as carrier and Aerosil 200 as coating material. Mathematical model and 32 factorial design with liquid load factor (X1) and drug concentration (X2) as the independent variables, was utilized to prepare the liquisolid powder systems. The prepared systems were subjected for studying micromeritic properties and possible drug-excipient interactions by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Dissolution studies revealed improvement in the drug release properties. Physicochemical characterization of liquisolid compacts by FTIR, DSC and PXRD techniques suggested reduction in drug crystallinity elaborating for the dissolution enhancement. The study reveals that liquisolid technique is a promising alternative for enhancing dissolution characteristics of EBN.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  • Ansel HC, Allen LV, Popovich NG (1999) Pharmaceutical dosage forms and drug delivery systems, 7th edn. Lippincott Williams and Wilkins, Philadelphia, pp 60–63

    Google Scholar 

  • Chitra M, Shyamala Devi CS, Sukumar E (2003) Antibacterial activity of embelin. Fitoterapia 74(4):401–403

    Article  PubMed  CAS  Google Scholar 

  • Elkordy AA, Tiong N (2009) Effects of liquisolid formulations on dissolution of naproxen. Eur J Pharm Biopharm 73:373–384

    Article  PubMed  Google Scholar 

  • Elkordy AA, Essa EA, Dhuppad S, Jammigumpula P (2012) Liquisolid technique to enhance and to sustain griseofulvin dissolution: effect of choice of non-volatile liquid vehicles. Int J Pharm 434:122–132

    Article  PubMed  CAS  Google Scholar 

  • Elkordy AA, Tan XN, Essa EA (2013) Spironolactone release from liquisolid formulations prepared with Capryol™ 90, Solutol HS-15 and Kollicoat SR 30 D as non-volatile liquid vehicles. Eur J Pharm Biopharm 83:203–223

    Article  PubMed  CAS  Google Scholar 

  • Gosangari S, Dyakonov T (2013) Enhanced dissolution performance of curcumin with the use of supersaturable formulations. Pharm Dev Technol 18(2):475–480

    Article  PubMed  CAS  Google Scholar 

  • Gubbi SR, Jarag R (2010) Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Sci 5(2):50–60

    Google Scholar 

  • Gupta R, Sharma AK, Sharma MC, Gupta RS (2012) Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes. J Diabetes 4(3):248–256

    Article  PubMed  CAS  Google Scholar 

  • Hussein A, Afouna M, El-Menshave S (2012) Enhancement of the in vitro dissolution and in vivo oral bioavailability of silymarin from liquid-filled hard gelatin capsules of semisolid dispersion using Gelucire 44/14 as a carrier. Pharmazie 67(3):209–214

    PubMed  CAS  Google Scholar 

  • Joy B, Lakshmi S (2010) Antiproliferative properties of embelia ribes. Open Proc Chem J 3:17–22

    CAS  Google Scholar 

  • Padh H, Patel BV (2001) Herbal drugs. Curr Sci 81:15–16

    Google Scholar 

  • Pathan RA, Bhandari U (2012) Preparation and characterization of embelin-phospholipid complex as effective drug delivery tool. J Incl Phenom Macro Chem 69:139–147

    Article  Google Scholar 

  • Radhakrishnan N, Alam M (1975) Antifertility effects of embelin in albino rats. Indian J Exp Biol 13(1):70–71

    PubMed  CAS  Google Scholar 

  • Sayyad FJ, Tulsankar SL, Kolap UB (2013) Design and development of liquisolid compact of candesartancilexetil to enhance dissolution. J Pharm Res 10:1–8

    Google Scholar 

  • Sikarwar MS, Sharma S, Jain AK, Parial SD (2008) Preparation, characterization and evaluation of marsupsin–phospholipidcomplex. AAPS PharmSciTech 9:129–137

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Spireas S (2002) Liquisolid systems and methods of preparing same US Patent 6423339B1

  • Tripathi SN (1979) Screening of hypoglycemic action in certain indigenous drugs. J Res Ind Med 14:159–169

    Google Scholar 

  • Vaskula S, Vemula S, Bontha V, Garepally P (2012) Liquisolid compacts: an approach to enhance the dissolution rate of Nimesulide. J App Pharm Sci 2(5):115–121

    CAS  Google Scholar 

  • Yousef J, Baharak Jafari N, Ali N (2007) Liquisolid technique for dissolution rate enhancement of high dose water insoluble drug (carbamazepine). Int J Pharm 341:26–34

    Article  Google Scholar 

Download references

Acknowledgments

This article dose not contain any studies with human and animal subjects performed by any of the authors. All authors (K. Parmar, J. Patel, and N. Sheth) declare that they have no conflict of interest. The authors are thankful to Mr. Swapnil Goyal (Asst. Prof. BR Nahta College of Pharmacy, Mandsaur) for providing the gift sample of EBN. The support of Gattefose, Mumbai is gratefully acknowledged to provide the gift sample of Capryol 90.

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, 360005, Gujarat, India

    Komal Parmar & Navin Sheth

  2. Nootan Pharmacy College, Visnagar, 384315, Gujarat, India

    Jayvadan Patel

Authors
  1. Komal Parmar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jayvadan Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Navin Sheth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Komal Parmar.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parmar, K., Patel, J. & Sheth, N. Fabrication and characterization of liquisolid compacts of Embelin for dissolution enhancement. Journal of Pharmaceutical Investigation 44, 391–398 (2014). https://doi.org/10.1007/s40005-014-0134-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40005-014-0134-3

Keywords

Search

Navigation