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Chitosan reinforced alginate controlled release beads of losartan potassium: design, formulation and in vitro evaluation

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Abstract

The work investigates the development and optimization of chitosan-alginate beads containing Losartan potassium (LP) through ionotropic/external gelation technique using 32 factorial design. The effect of polymer-blend concentrations i.e. chitosan and sodium alginate on the drug encapsulation efficiency (DEE%), and cumulative drug release after 20 h (R20h %) was optimized. The DEE% of all these beads was within the range of 67.12 ± 1.97–89.81 ± 1.52 % with sustained in vitro drug release of 80.98–97.13 % over 20 h. The in vitro drug release from these beads was followed first order kinetic model. The beads were also characterized by FE-SEM, FTIR and XRD analysis. The swelling of chitosan–alginate beads containing LP were influenced by the pH of the test medium. Chitosan coated alginate beads were developed as oral sustained delivery carriers for LP in order to improve patient compliance, to reduce side effects associated with it and also to reduce the dose/dosing frequency in the management of hypertension.

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Acknowledgments

The authors are grateful to Defence Research and Development Organisation (DRDO) New Delhi, Govt. of India, for providing financial support, in terms of Extramural Research Project [ERIP/ER/0903820/M/01/1379]. The authors also like to thank Merlin Pharma Pvt. Ltd. Mumbai, Maharashtra, India for providing Losartan potassium free sample of drug and India Sea Foods, Chitin Division, Kannamaly, Kochi-8, India, for providing chitosan as a gift sample.

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Authors have no conflict of interest regarding this article.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University Institute of Chemical Technology (UICT), North Maharashtra University, P. B. No. 80, Umavi Nagar, Jalgaon, 425 001, Maharashtra, India

    Vinod Mokale, Naik Jitendra, Sutar Yogesh & Khairnar Gokul

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  1. Vinod Mokale
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  2. Naik Jitendra
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  3. Sutar Yogesh
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Correspondence to Vinod Mokale.

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Mokale, V., Jitendra, N., Yogesh, S. et al. Chitosan reinforced alginate controlled release beads of losartan potassium: design, formulation and in vitro evaluation. Journal of Pharmaceutical Investigation 44, 243–252 (2014). https://doi.org/10.1007/s40005-014-0122-7

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