Abstract
The aim of the current study was to develop a sustained release asymmetric membrane capsular system for oral delivery of indomethacin. The capsule membrane was prepared using fabricated glass mold pins by phase inversion technique. Cellulose acetate was used as the semi permeable membrane. The capsule contains pore-forming water-soluble additives, which after coming in contact with aqueous medium, dissolves, resulting in an in situ formation of a micro porous structure. The effect of different formulation variables, like, ratio of drug to osmogen, solubilizing agent and level of pore former, stirring rate on the in vitro release was studied. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. It was found that drug release rate increased with the increase in amount of osmogen and solubilizer, and independent of stirring rate. Indomethacin release was, directly proportional to the level of pore former, in the membrane. In the present investigation, efforts have been made to increase the release of poorly water soluble drug by means of porosity osmotic pump.
Similar content being viewed by others
References
Agrawal S, Pancholi SS, Jain NK, Agrawal GP (2004) Hydrotropic solubilization of nimesulide for parenteral administration. Int J Pharm 274:149–155
Chauhan CS, Ranawat MS, Choudhury PK (2007) Fabrication and evaluation of asymmetric membrane osmotic pump. Indian J Pharm Sci 69(6):748–752
Choudhury PK, Ranawat MS, Pillai MK, Chauhan CS (2007) Asymmetric membrane capsule for osmotic delivery of flurbiprofen. Acta Pharm 57:343–350
Gaurve K, Gupta GD (2010) Asymmetric membrane capsules for extended delivery of the weakly basic drug carvedilol. Pharmaceutics 2(2):199–208
Guarve K, Gupta GD (2009) Development and in vitro evaluation of osmotically controlled oral drug delivery system of carvedilol. Int J Pharm Sci Drug Res 1(2):80–82
Indian Pharmacopoeia (2007) The Indian Pharmacopoeia Commission, Central Indian Pharmacopoeia Laboratory, Ministry of Health and Family Welfare, Government of India, Ghaziabad. vol 2, pp 1227–1228
Jain AK (2008) Solubilization of indomethacin using hydrotropes for aqueous injection. Eur J Pharm Biopharm 68:701–714
Kapoor D, Chauhan CS, Gupta AK (2011) Formulation and evaluation of controlled porosity osmotic pump of valsartan. Int J Pharm Biol Arch 2(3):967–972
Kumar L, Shivani, Kumar A, Parashar D, Bhadra S (2012) Asymmetric membrane capsule (AMC): an useful osmotic drug delivery system. Int J Pharm Pharm Sci 4(2):54–59
Lin YK, Ho HO (2003) Investigations on the drug releasing mechanism from an asymmetric membrane-coated capsule with an in situ formed delivery orifice. J Control Release 89:57–69
Malaterre V, Ogorka J, Loggia N, Gurny R (2009) Oral osmotically driven systems: 30 years of development and clinical use. Eur J Pharm Biopharm 73:311–323
Philip AK, Pathak K (2006) Osmotic flow through asymmetric membrane: a means for controlled delivery of drugs with varying solubility. AAPS PharmSciTech 7(3):E1–E11
Philip AK, Pathak K (2007) Dry process induced phase transited drug delivery system: a means for delivery of a GI irritant drug. Ethiop Pharm J 25(2):121–130
Philip AK, Pathak K, Shakya P (2007) Asymmetric membrane in membrane capsules: a means for achieving delayed and osmotic flow of cefadroxil. Eur J Pharm Biopharm 69:658–666
Prabakaran D, Singh P, Jaganathan KS, Vyas SP (2004) Osmotically regulated asymmetric capsular systems for simultaneous sustained delivery of anti-tubercular drugs. J Control Release 95:239–248
Thombre AG, Cardinal JR, DeNoto AR, Herbig SM, Smith KL (1999a) Asymmetric membrane capsules for osmotic drug delivery I. Development of a manufacturing process. J Control Release 57:55–64
Thombre AG, Cardinal JR, DeNoto AR, Gibbes DC (1999b) Asymmetric membrane capsules for osmotic drug delivery II. In vitro and in vivo drug release performance. J Control Release 57:65–73
Tripathi KD (2003) Essential of Medical Pharmacology. Jaypee Brothers Medical Publishers, New Delhi, pp 175–176
Wang CY, Ho HO, Lin LH, Lin YK, Sheu MT (2005) Asymmetric membrane capsules for delivery of poorly water-soluble drugs by osmotic effects. Int J Pharm 297:89–97
Acknowledgments
The authors are grateful to Neon Laboratories Limited, Mumbai, India for supplying the gift samples of drug indomethacin. We are also thankful to Pragati Sales Corporation, Electronic complex, Indore, India for the fabrication of glass mold pins. Sincere gratitude is also extended towards the College of Pharmacy, IPS Academy, Indore, India, for providing necessary facilities.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jain, D.K., Darwhekar, G., Solanki, S.S. et al. Osmotically regulated asymmetric capsular system for sustained delivery of indomethacin. Journal of Pharmaceutical Investigation 43, 27–35 (2013). https://doi.org/10.1007/s40005-012-0050-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40005-012-0050-3