Skip to main content
Log in

Osmotically regulated asymmetric capsular system for sustained delivery of indomethacin

  • Research Article
  • Published:
Journal of Pharmaceutical Investigation Aims and scope Submit manuscript

Abstract

The aim of the current study was to develop a sustained release asymmetric membrane capsular system for oral delivery of indomethacin. The capsule membrane was prepared using fabricated glass mold pins by phase inversion technique. Cellulose acetate was used as the semi permeable membrane. The capsule contains pore-forming water-soluble additives, which after coming in contact with aqueous medium, dissolves, resulting in an in situ formation of a micro porous structure. The effect of different formulation variables, like, ratio of drug to osmogen, solubilizing agent and level of pore former, stirring rate on the in vitro release was studied. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. It was found that drug release rate increased with the increase in amount of osmogen and solubilizer, and independent of stirring rate. Indomethacin release was, directly proportional to the level of pore former, in the membrane. In the present investigation, efforts have been made to increase the release of poorly water soluble drug by means of porosity osmotic pump.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  • Agrawal S, Pancholi SS, Jain NK, Agrawal GP (2004) Hydrotropic solubilization of nimesulide for parenteral administration. Int J Pharm 274:149–155

    Article  PubMed  CAS  Google Scholar 

  • Chauhan CS, Ranawat MS, Choudhury PK (2007) Fabrication and evaluation of asymmetric membrane osmotic pump. Indian J Pharm Sci 69(6):748–752

    Article  CAS  Google Scholar 

  • Choudhury PK, Ranawat MS, Pillai MK, Chauhan CS (2007) Asymmetric membrane capsule for osmotic delivery of flurbiprofen. Acta Pharm 57:343–350

    Article  PubMed  CAS  Google Scholar 

  • Gaurve K, Gupta GD (2010) Asymmetric membrane capsules for extended delivery of the weakly basic drug carvedilol. Pharmaceutics 2(2):199–208

    Article  Google Scholar 

  • Guarve K, Gupta GD (2009) Development and in vitro evaluation of osmotically controlled oral drug delivery system of carvedilol. Int J Pharm Sci Drug Res 1(2):80–82

    CAS  Google Scholar 

  • Indian Pharmacopoeia (2007) The Indian Pharmacopoeia Commission, Central Indian Pharmacopoeia Laboratory, Ministry of Health and Family Welfare, Government of India, Ghaziabad. vol 2, pp 1227–1228

  • Jain AK (2008) Solubilization of indomethacin using hydrotropes for aqueous injection. Eur J Pharm Biopharm 68:701–714

    Article  PubMed  CAS  Google Scholar 

  • Kapoor D, Chauhan CS, Gupta AK (2011) Formulation and evaluation of controlled porosity osmotic pump of valsartan. Int J Pharm Biol Arch 2(3):967–972

    Google Scholar 

  • Kumar L, Shivani, Kumar A, Parashar D, Bhadra S (2012) Asymmetric membrane capsule (AMC): an useful osmotic drug delivery system. Int J Pharm Pharm Sci 4(2):54–59

    CAS  Google Scholar 

  • Lin YK, Ho HO (2003) Investigations on the drug releasing mechanism from an asymmetric membrane-coated capsule with an in situ formed delivery orifice. J Control Release 89:57–69

    Article  PubMed  CAS  Google Scholar 

  • Malaterre V, Ogorka J, Loggia N, Gurny R (2009) Oral osmotically driven systems: 30 years of development and clinical use. Eur J Pharm Biopharm 73:311–323

    Article  PubMed  Google Scholar 

  • Philip AK, Pathak K (2006) Osmotic flow through asymmetric membrane: a means for controlled delivery of drugs with varying solubility. AAPS PharmSciTech 7(3):E1–E11

    Article  Google Scholar 

  • Philip AK, Pathak K (2007) Dry process induced phase transited drug delivery system: a means for delivery of a GI irritant drug. Ethiop Pharm J 25(2):121–130

    CAS  Google Scholar 

  • Philip AK, Pathak K, Shakya P (2007) Asymmetric membrane in membrane capsules: a means for achieving delayed and osmotic flow of cefadroxil. Eur J Pharm Biopharm 69:658–666

    Article  PubMed  Google Scholar 

  • Prabakaran D, Singh P, Jaganathan KS, Vyas SP (2004) Osmotically regulated asymmetric capsular systems for simultaneous sustained delivery of anti-tubercular drugs. J Control Release 95:239–248

    Article  PubMed  CAS  Google Scholar 

  • Thombre AG, Cardinal JR, DeNoto AR, Herbig SM, Smith KL (1999a) Asymmetric membrane capsules for osmotic drug delivery I. Development of a manufacturing process. J Control Release 57:55–64

    Article  PubMed  CAS  Google Scholar 

  • Thombre AG, Cardinal JR, DeNoto AR, Gibbes DC (1999b) Asymmetric membrane capsules for osmotic drug delivery II. In vitro and in vivo drug release performance. J Control Release 57:65–73

    Article  PubMed  CAS  Google Scholar 

  • Tripathi KD (2003) Essential of Medical Pharmacology. Jaypee Brothers Medical Publishers, New Delhi, pp 175–176

    Google Scholar 

  • Wang CY, Ho HO, Lin LH, Lin YK, Sheu MT (2005) Asymmetric membrane capsules for delivery of poorly water-soluble drugs by osmotic effects. Int J Pharm 297:89–97

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to Neon Laboratories Limited, Mumbai, India for supplying the gift samples of drug indomethacin. We are also thankful to Pragati Sales Corporation, Electronic complex, Indore, India for the fabrication of glass mold pins. Sincere gratitude is also extended towards the College of Pharmacy, IPS Academy, Indore, India, for providing necessary facilities.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dinesh Kumar Jain.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jain, D.K., Darwhekar, G., Solanki, S.S. et al. Osmotically regulated asymmetric capsular system for sustained delivery of indomethacin. Journal of Pharmaceutical Investigation 43, 27–35 (2013). https://doi.org/10.1007/s40005-012-0050-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40005-012-0050-3

Keywords

Navigation