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Hepatitis B and immigrants: a SIMIT multicenter cross-sectional study

  • Clinical and Epidemiological Study
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Abstract

Background

The continuing migration of individuals from geographic areas with high/medium endemicity has determined the arrival of new chronic hepatitis B virus (HBV) carriers in Italy. The magnitude of this phenomenon and clinical/virological features of HBsAg-positive migrants remain not very well defined.

Aims

To evaluate the proportion of HBsAg-positive immigrants enrolled in this multicenter Società Italiana di Malattie Infettive e Tropicali (SIMIT) cross-sectional study and to compare the characteristics of chronic hepatitis B infection in migrants to those of Italian carriers.

Methods

From February 1 to July 31 2008, anonymous data were obtained from all HBsAg-positive patients aged ≥18 years observed at 74 Italian centers of infectious diseases.

Results

Of the 3,760 HBsAg-positive subjects enrolled, 932 (24.8 %) were immigrants, with a prevalent distribution in central to northern Italy. The areas of origin were: Far East (37.1 %), Eastern Europe (35.4 %), Sub-Saharan Africa (17.5 %), North Africa (5.5 %), and 4.5 % from various other sites. Compared to Italian carriers, migrants were significantly younger (median age 34 vs. 52 years), predominantly female (57.5 vs. 31 %), and most often at first observation (incident cases 34.2 vs. 13.3 %). HBeAg-positives were more frequent among migrants (27.5 vs. 14 %). Genotype D, found in 87.8 % of Italian carriers, was present in only 40 % of migrants, who were more frequently inactive HBV carriers, with a lower prevalence of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Only 27.1 % of migrants received antiviral treatment compared to 50.3 % of Italians.

Conclusions

Twenty-five percent of all HBV carriers examined at Italian centers was composed of immigrants with demographic, serological, and virological characteristics that differed from those of natives and appeared to have an inferior access to treatment.

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Acknowledgments

The authors are grateful to Ms. Paulene Butts for her assistance in the preparation of the manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Clinic of Infectious Diseases, University of Bari, Bari, Italy

    M. Fasano & G. Angarano

  2. Clinic of Infectious Diseases, University of Foggia, Ospedali Riuniti, Viale Pinto 1, 71100, Foggia, Italy

    A. Saracino & T. Santantonio

  3. Tropical and Infectious Diseases, University of Brescia, Brescia, Italy

    G. Carosi

  4. Clinic of Infectious Diseases, Hospital of S.M. Annunziata, Florence, Italy

    F. Mazzotta & N. Marino

  5. Clinic of Infectious Diseases, University of Caserta, Caserta, Italy

    E. Sagnelli

  6. Clinic of Infectious Diseases, II University of Napoli, Naples, Italy

    G. B. Gaeta

  7. Clinic of Infectious Diseases, University of Bologna, Bologna, Italy

    G. Verucchi

  8. Clinic of Infectious Diseases, A.O. “Gravina”, Caltagirone, Italy

    P. Bellissima

  9. UOC Epidemiologia Clinica, Istituto Nazionale Malattie Infettive L. Spallanzani—IRCCS, Rome, Italy

    C. Angeletti

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  1. M. Fasano
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  2. A. Saracino
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  3. G. Carosi
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  4. F. Mazzotta
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  5. N. Marino
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  6. E. Sagnelli
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  7. G. B. Gaeta
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  8. G. Angarano
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  9. G. Verucchi
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  10. P. Bellissima
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  11. C. Angeletti
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  12. T. Santantonio
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Corresponding author

Correspondence to T. Santantonio.

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Fasano, M., Saracino, A., Carosi, G. et al. Hepatitis B and immigrants: a SIMIT multicenter cross-sectional study. Infection 41, 53–59 (2013). https://doi.org/10.1007/s15010-012-0384-9

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  • DOI: https://doi.org/10.1007/s15010-012-0384-9

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