Case Report

Infection

, Volume 41, Issue 1, pp 225-229

Transient reactivation of occult hepatitis B virus infection despite lamivudine prophylaxis in a patient treated for non-Hodgkin lymphoma

  • Gilda TonzielloAffiliated withDepartment of Public Medicine, Section of Infectious Diseases, Second University of Naples
  • , Marintonietta PisaturoAffiliated withDepartment of Public Medicine, Section of Infectious Diseases, Second University of Naples
  • , Antonello SicaAffiliated withHaematology Unit, Second University of Naples
  • , Maria Giovanna FerraraAffiliated withHaematology Unit, Second University of Naples
  • , Caterina SagnelliAffiliated withDepartment of Clinical and Experimental Medicine and Surgery “F Magrassi e A Lanzara”, Second University of Naples
  • , Giuseppe PasqualeAffiliated withDepartment of Public Medicine, Section of Infectious Diseases, Second University of Naples
  • , Evangelista SagnelliAffiliated withDepartment of Public Medicine, Section of Infectious Diseases, Second University of Naples Email author 
  • , Salvatore GuastafierroAffiliated withHaematology Unit, Second University of Naples
  • , Nicola CoppolaAffiliated withDepartment of Public Medicine, Section of Infectious Diseases, Second University of Naples

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Abstract

A female patient with non-Hodgkin lymphoma who tested positive for surface antigen of the hepatitis B virus and negative for hepatitis B core antibody experienced a reactivation of occult HBV infection 20 months after rituximab discontinuation despite lamivudine prophylaxis covering the 4 months of rituximab administration and the subsequent 12 months.

Keywords

Occult HBV infection Rituximab Lamivudine prophylaxis Immunosuppressive diseases Onco-hematological diseases