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Magnetic solid-phase extraction of imatinib and doxorubicin as cytostatic drugs by Fe3O4/graphene oxide nanocomposite

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Abstract

Magnetic solid-phase extraction based on Fe3O4/graphene oxide nanocomposites was investigated for the separation, preconcentration and determination of imatinib and doxorubicin in aqueous solutions. Synthesis of Fe3O4/graphene oxide was characterized by transmission electron microscopy, energy-dispersive X-ray analyzer and vibrating sample magnetometer. After optimizing the conditions, optimal experimental conditions including sample pH, the amount of the magnetic nanoparticles, the effect of salt concentration and other chemotherapy medications, eluent type and extraction time were studied and established. The method showed good linearity for the determination of doxorubicin and imatinib in the concentration range of 0.01–100 μg mL−1 in aqueous solutions with limit of detection 1.8 ng mL−1 for doxorubicin and 1.9 ng mL−1 for imatinib. The relative recoveries of doxorubicin and imatinib levels were 96.7 and 88.4%, respectively. The results indicate that the present procedure is a suitable method for extraction of imatinib and doxorubicin from environmental water samples.

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Acknowledgements

We gratefully acknowledge the University of Guilan (Grant No. BS2458/1393) and Sobhan Oncology Pharmaceutical Company (the company is located in the industrial city of Rasht in Guilan province), for supporting this work.

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Authors and Affiliations

  1. Electroanalytical Chemistry Laboratory, Faculty of Science, University of Guilan, Namjoo Street, P.O. Box 1914, Rasht, Iran

    Majid Arvand

  2. Department of Chemistry, Pardis Campus, University of Guilan, Park-e-Shahr, P.O. Box 4199613776, Rasht, Iran

    Majid Arvand & Afshin Nickdoust Masouleh

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  1. Majid Arvand
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  2. Afshin Nickdoust Masouleh
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Correspondence to Majid Arvand.

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Arvand, M., Masouleh, A.N. Magnetic solid-phase extraction of imatinib and doxorubicin as cytostatic drugs by Fe3O4/graphene oxide nanocomposite. J IRAN CHEM SOC 14, 1673–1682 (2017). https://doi.org/10.1007/s13738-017-1108-y

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