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Synthesis and anti-brucella activity of some new 1,3,4-oxadiazole derivatives containing a ferrocene unit

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Abstract

An isocyanide-based multicomponent reaction between cinnamic acid derivatives or 3-phenyl-2-propynoic acid, (N-isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde, and dibenzylamine has been reported in excellent yields for the preparation of some new ferrocenyl-containing 1,3,4-oxadiazole derivatives. The anti-brucella activities of the products are investigated in in vitro and in vivo assays.

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Acknowledgments

We would like to express appreciation to Iran National Science Foundation (INSF) for the generous support that made our contribution to this research possible.

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Authors and Affiliations

  1. Research Laboratory of MCR, Department of Chemistry, Zanjan Branch, Islamic Azad University, PO Box 49195-467, Zanjan, Iran

    Ali Reza Kazemizadeh & Nahid Shajari

  2. Department of Microbiology, Zanjan Branch, Islamic Azad University, PO Box 49195-467, Zanjan, Iran

    Reza Shapouri

  3. Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184, Zanjan, Iran

    Neda Adibpour

  4. Organic Synthesis Research Laboratory, Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, 51664, Tabriz, Iran

    Reza Teimuri-Mofrad

Authors
  1. Ali Reza Kazemizadeh
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  2. Nahid Shajari
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  3. Reza Shapouri
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  4. Neda Adibpour
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  5. Reza Teimuri-Mofrad
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Correspondence to Ali Reza Kazemizadeh.

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Kazemizadeh, A.R., Shajari, N., Shapouri, R. et al. Synthesis and anti-brucella activity of some new 1,3,4-oxadiazole derivatives containing a ferrocene unit. J IRAN CHEM SOC 13, 1349–1355 (2016). https://doi.org/10.1007/s13738-016-0849-3

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  • DOI: https://doi.org/10.1007/s13738-016-0849-3

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