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Catalyst-free and selective oxidation of pyridine derivatives and tertiary amines to corresponding N-oxides with 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane

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Abstract

The catalyst-free oxidation of various pyridine derivatives and tertiary amines to their corresponding N-oxides with 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane as an efficient oxidant has been developed. The methodology proved to tolerate a number of functional groups. The reactions proceeded smoothly under solvent-free and mild conditions at room temperature. All the products were easily extracted from the reaction mixtures in excellent yields.

Graphical abstract

The catalyst-free oxidation of various pyridine derivatives and tertiary amines to their corresponding N-oxides with 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane as an efficient oxidant has been developed. The methodology proved to tolerate a number of functional groups. The reactions proceeded smoothly under solvent-free and mild conditions at room temperature. All the products were easily extracted from the reaction mixtures in excellent yields.

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Acknowledgments

The authors wish to thank the Research Council of Bu-Ali Sina University for financial support to carry out this research.

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Authors and Affiliations

  1. Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 65178, Iran

    Davood Azarifar & Boshra Mahmoudi

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  1. Davood Azarifar
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  2. Boshra Mahmoudi
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Correspondence to Davood Azarifar.

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Azarifar, D., Mahmoudi, B. Catalyst-free and selective oxidation of pyridine derivatives and tertiary amines to corresponding N-oxides with 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane. J IRAN CHEM SOC 13, 645–651 (2016). https://doi.org/10.1007/s13738-015-0776-8

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  • DOI: https://doi.org/10.1007/s13738-015-0776-8

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