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Synthesis of novel 5-arylidene (thio)barbituric acid and evaluation of their urease inhibitory activity

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Abstract

A simple and practical method is described for the synthesis of novel 5-arylidene derivatives of barbituric and thiobarbituric acid. 2-Formylbenzoic acids reacted easily with (thio)barbituric acids in the presence of p-toluenesulfonic acid (p-TsOH) in MeOH/EtOH to obtain the title compound in good yields. Then, their urease inhibitory activity were evaluated in vitro and compared with hydroxyurea as the reference drug.

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Acknowledgments

The authors gratefully acknowledge the research council of Tehran University of Medical Sciences and Iran National Science Foundation (INSF).

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Correspondence to Abbas Shafiee.

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Vosooghi, M., Farzipour, S., Saeedi, M. et al. Synthesis of novel 5-arylidene (thio)barbituric acid and evaluation of their urease inhibitory activity. J IRAN CHEM SOC 12, 1487–1491 (2015). https://doi.org/10.1007/s13738-015-0617-9

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  • DOI: https://doi.org/10.1007/s13738-015-0617-9

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