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Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance

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Abstract

Proximal tubules are a target for paraproteinemic diseases. Cast nephropathy, light chain deposition diseases, and amyloidosis are frequently encountered in patients with multiple myeloma. Rarely, a subset of patients develop light chain Fanconi syndrome (LCFS). LCFS has been reported with multiple myeloma, monoclonal gammopathy of renal significance (MGRS), chronic lymphocytic leukemia, Waldenstrom’s macroglobulinemia and diffuse large B-cell lymphoma. No cases have been described with other hematologic malignancies. We report the first case of lambda LCFS in a patient with both acute myeloid leukemia (AML) and monoclonal gammopathy of undetermined significance (MGUS).

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Authors and Affiliations

  1. Division of Kidney Diseases and Hypertension, Department of Medicine, Hofstra Northwell School of Medicine, 450 Lakeville Road, Lake Success, NY, 11042, USA

    Daniel W. Ross, Rimda Wanchoo & Kenar D. Jhaveri

  2. Division of Hematology, Department of Medicine, Hofstra Northwell School of Medicine, 450 Lakeville Road, Lake Success, NY, 11042, USA

    Adriana Guigova, Cristina Ghiuzeli & Steven L. Allen

Authors
  1. Daniel W. Ross
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  2. Rimda Wanchoo
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  3. Adriana Guigova
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  4. Cristina Ghiuzeli
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  5. Steven L. Allen
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  6. Kenar D. Jhaveri
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Corresponding author

Correspondence to Daniel W. Ross.

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The authors have no conflicts of interest and have no disclosures. No patient identifying information is presented in this case report.

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Ross, D.W., Wanchoo, R., Guigova, A. et al. Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance. CEN Case Rep 5, 238–241 (2016). https://doi.org/10.1007/s13730-016-0232-3

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  • DOI: https://doi.org/10.1007/s13730-016-0232-3

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