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Partial remission by cyclosporine monotherapy in a patient with membranous nephropathy superimposed diabetic nephropathy

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Abstract

It has been noted that cyclosporine A (CsA) is an effective drug for membranous nephropathy (MN). Diabetes is a common disease that sometimes causes nephrotic syndrome. We report the case of an 89-year-old woman with type 2 diabetes mellitus who exhibited nephrotic syndrome. Examination of a renal biopsy indicated MN and she was prescribed CsA as monotherapy. Her edema subsided and she achieved partial remission. This is the first report of a patient in diabetic condition with MN having achieved partial remission after CsA monotherapy without steroid therapy. The use of steroid in patients with diabetes may worsen their diabetic condition, especially if they are of very advanced age. CsA monotherapy may be useful for diabetic patients with MN.

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References

  1. Soleymanian T, et al. Non-diabetic renal disease with or without diabetic nephropathy in type 2 diabetes: clinical predictors and outcome. Ren Fail. 2015;37(4):572–5.

    Article  CAS  PubMed  Google Scholar 

  2. Beck L, et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis. Am J Kidney Dis. 2013;62(3):403–41.

    Article  PubMed  Google Scholar 

  3. Pham TT, et al. Prevalence of nondiabetic renal disease in diabetic patients. Am J Nephrol. 2007;27(3):322–8.

    Article  PubMed  Google Scholar 

  4. Shiiki H, et al. Prognosis and risk factors for idiopathic membranous nephropathy with nephrotic syndrome in Japan. Kidney Int. 2004;65(4):1400–7.

    Article  PubMed  Google Scholar 

  5. Hogan SL, et al. A review of therapeutic studies of idiopathic membranous glomerulopathy. Am J Kidney Dis. 1995;25(6):862–75.

    Article  CAS  PubMed  Google Scholar 

  6. Howman A, et al. Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial. Lancet. 2013;381(9868):744–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Iida H, et al. Effect of cyclosporine therapy on idiopathic membranous nephropathy presented with refractory nephrotic syndrome. Clin Exp Nephrol. 2000;4:81–5.

    Article  CAS  Google Scholar 

  8. Alexopoulos E, et al. Induction and long-term treatment with cyclosporine in membranous nephropathy with the nephrotic syndrome. Nephrol Dial Transplant. 2006;21(11):3127–32.

    Article  CAS  PubMed  Google Scholar 

  9. Polanco N, et al. Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy. J Am Soc Nephrol. 2010;21(4):697–704.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of General Internal Medicine 1, Kawasaki Medical School, Kawasaki Hospital, 2-1-80 Nakasange, Kita-ku, Okayama, 700-8505, Japan

    Yoshiyuki Oshiro, Hisataka Tanaka, Fumiko Kawasaki & Niro Okimoto

Authors
  1. Yoshiyuki Oshiro
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  2. Hisataka Tanaka
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  3. Fumiko Kawasaki
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  4. Niro Okimoto
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Corresponding author

Correspondence to Yoshiyuki Oshiro.

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The authors have declared that no Conflict of interest exists.

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Oshiro, Y., Tanaka, H., Kawasaki, F. et al. Partial remission by cyclosporine monotherapy in a patient with membranous nephropathy superimposed diabetic nephropathy. CEN Case Rep 5, 219–222 (2016). https://doi.org/10.1007/s13730-016-0228-z

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  • DOI: https://doi.org/10.1007/s13730-016-0228-z

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