Abstract
Neurological complications are not uncommon in patients with renal transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. BK virus infection is relatively common in transplant recipients and in some cases may lead to neurological complications. In this report, we present an interesting case of a patient who developed acute axonal motor polyneuropathy in the course of BK virus infection 3 months after kidney transplantation. After BK virus clearence in blood, a significant improvement was noted in her polyneuropathy. In patients with acute axonal motor polyneuropathy after transplantation BK virus-induced polyneuropathy should be excluded.
Similar content being viewed by others
References
Ponticelli C, Campise MR. Neurological complications in kidney transplant recipients. J Nephrol. 2005;18:521–8.
Patel MK, Rashed A, Mesraoua B, Khaddash S, Romeh SA. Cyclosporine neurotoxicity presenting as an unilateral foot drop in a renal transplant patient. Nephron. 1991;58:116.
Chegounchi M, Hanna MG, Neild GH. Progressive neurological disease induced by tacrolimus in a renal transplant recipient: case presentation. BMC Nephrol. 2006;7:7.
Kaczmarek I, Schmauss D, Sodian R, Beiras-Fernandez A, Oberhoffer M, Daebritz S. Late-onset tacrolimus-associated cerebellar atrophia in a heart transplant recipient. J Heart Lung Transplant. 2007;26:2–89.
Boothpur R, Brennan DC. Human polyoma viruses and disease with emphasis on clinical BK and JC. J Clin Virol. 2010;47:306–12.
Vallbracht A, Löhler J, Gossmann J, Glück T, Petersen D, Gerth HJ, Gencic M, Dörries K. Disseminated BK type polyomavirus infection in an AIDS patient associated with central nervous system disease. Am J Pathol. 1993;143:9–29.
Voltz R, Jäger G, Seelos K, Fuhry L, Hohlfeld R. BK virus encephalitis in an immunocompetent patient. Arch Neurol. 1996;53:101–3.
Bratt G, Hammarin AL, Grandien M, Hedquist BG, Nennesmo I, Sundelin B, Seregard S. BK virus as the cause of meningoencephalitis, retinitis and nephritis in a patient with AIDS. AIDS. 1996;13:1071–5.
Hirsch HH, Mohaupt M, Klimkait T. Prospective monitoring of BK virus load after discontinuing sirolimus treatment in a renal transplant patient with BK virus nephropathy. J Infect Dis. 2001;184:1494–5.
Ramos E, Drachenberg CB, Papadimitriou JC, Hamze O, Fink JC, Klassen DK, Drachenberg RC, Wiland A, Wali R, Cangro CB, Schweitzer E, Bartlett ST, Weir MR. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol. 2002;13:2145–51.
Leung AY, Chan MT, Yuen KY, Cheng VC, Chan KH, Wong CL, Liang R, Lie AK, Kwong YL. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2005;40:528–33.
Randhawa PS. Anti-BK virus activity of ciprofloxacin and related antibiotics. Clin Infect Dis. 2005;41:1366–7.
Sener A, House AA, Jevnikar AM, Boudville N, McAlister VC, Muirhead N, Rehman F, Luke PP. Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation. 2006;81:117–20.
Conflict of interest
There is no conflict interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Taskapan, H., Kayabas, U., Otlu, B. et al. BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient. CEN Case Rep 5, 1–4 (2016). https://doi.org/10.1007/s13730-015-0179-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13730-015-0179-9