Original Paper

Iranian Polymer Journal

, Volume 21, Issue 2, pp 99-107

Preparation of alginate and chitosan nanoparticles using a new reverse micellar system

  • Morteza Hasanzadeh KafshgariAffiliated withDepartment of Chemical Engineering, University of Sistan and Baluchestan
  • , Mohammad KhorramAffiliated withDepartment of Chemical Engineering, University of Sistan and Baluchestan Email author 
  • , Mohsen MansouriAffiliated withDepartment of Chemical Engineering, University of Sistan and Baluchestan
  • , Abdolreza SamimiAffiliated withDepartment of Chemical Engineering, University of Sistan and Baluchestan
  • , Shahriar OsfouriAffiliated withDepartment of Chemical Engineering, Persian Gulf University

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Abstract

Alginate and chitosan nanoparticles were prepared using a new reverse micelle system, composed of cetyltrimethylammonium bromide (CTAB) as a surfactant, isooctane as a solvent, and 1-hexananol as a co-solvent. The obtained nanoparticles were characterized by FTIR, DLS and TEM techniques. The main objective of this study was to investigate the effects of polymer concentration, water content, and volumetric ratio of co-solvent to solvent on the physical and morphological properties of the prepared nanoparticles. To evaluate the results, the design of experimental was initially carried out and then the obtained data were statistically analyzed using the Qualitek-4® software. Results revealed that the size of the prepared alginate and chitosan nanoparticles varied in the range 220–490 and 210–1,050 nm, respectively. Furthermore, increasing either alginate or chitosan concentration increased the size of their nanoparticles. The results also showed that the size of nanoparticles was decreased with increasing the volumetric ratio of co-solvent/solvent. Finally, the size of alginate nanoparticles was increased by increasing the water content while it decreased the size of chitosan nanoparticles. Considering the statistical analysis of experiments, the polymer concentration is the major parameter affecting nanoparticles’ size. In contrast, water content has the smallest effect on the size of nanoparticles. However, the difference between the particle sizes of chitosan and alginate nanoparticles cab be attributed to the electrostatic repulsion between chitosan and CTAB.

Keywords

Reverse Micelle CTAB Nanoparticles Chitosan Alginate