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Novel combination chemotherapy with radiotherapy for prostate squamous cell carcinoma

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Abstract

Squamous cell carcinoma of the prostate is a rare tumor. It has been typically described as an aggressive cancer, with a median survival time of 14 months. We present a case of locally advanced squamous cell carcinoma of the prostate with a regional lymph node metastasis. The patient received a novel combination chemotherapy regimen, docetaxel, cisplatin, and 5-fluorouracil, with radiotherapy to the whole pelvis and prostate. He was subsequently treated with seven courses of docetaxel, cisplatin, and 5-fluorouracil chemotherapy without any severe adverse events. We identified a 60.1 % reduction in the prostatic tumor, and the lymph node metastasis was shrunk after chemotherapy. A needle biopsy of the prostate after chemotherapy revealed no malignancy. No recurrence has been observed for 24 months. A combination of docetaxel, cisplatin, and 5-fluorouracil chemotherapy and radiotherapy might be an effective therapy for squamous cell carcinoma of the prostate.

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Authors and Affiliations

  1. Department of Urology, Iwate Medical University School of Medicine, Morioka, Japan

    Mitsutaka Onoda, Misato Takayama, Ei Shiomi, Renpei Kato, Yoichiro Kato, Ryo Takata, So Omori & Wataru Obara

  2. Department of Molecular Diagnostic Pathology, Iwate Medical University School of Medicine, Morioka, Japan

    Ryo Sugimoto & Noriyuki Uesugi

Authors
  1. Mitsutaka Onoda
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  2. Ryo Sugimoto
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  3. Noriyuki Uesugi
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  4. Misato Takayama
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  5. Ei Shiomi
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  6. Renpei Kato
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  7. Yoichiro Kato
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  8. Ryo Takata
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  9. So Omori
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  10. Wataru Obara
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Corresponding author

Correspondence to Mitsutaka Onoda.

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The authors declare that they have no conflict of interest.

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Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

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Onoda, M., Sugimoto, R., Uesugi, N. et al. Novel combination chemotherapy with radiotherapy for prostate squamous cell carcinoma. Int Canc Conf J 6, 25–28 (2017). https://doi.org/10.1007/s13691-016-0266-6

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  • DOI: https://doi.org/10.1007/s13691-016-0266-6

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