Skip to main content

Advertisement

SpringerLink
Log in

Metachronous multiple thymoma with different clinical behavior and pathological findings

  • Case report
  • Published:
International Cancer Conference Journal Aims and scope Submit manuscript

Abstract

A 70-year-old woman presented with a nodule in the left hilum on a chest radiograph 3 years before. Another mass emerged caudal to the initial nodule and was diagnosed as thymoma. A surgical specimen revealed two components: an encapsulated rostral nodule and a caudal mass invading the left lung. Histological findings showed that the rostral nodule was a stage 1 type B2 thymoma, whereas the caudal mass was a stage 3 type B3 thymoma. Based on the differences in biological behavior and histological findings, we concluded that these tumors derived from multicentric origin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Abbreviations

MG:

Myasthenia gravis

CT:

Computed tomography

WHO:

World Health Organization

References

  1. Bernatz PE, Harrison EG, Clagett OT (1961) Thymoma: a clinicopathologic study. J Thorac Cardiovasc Surg 42:424–444

    CAS  PubMed  Google Scholar 

  2. Jaretzki A 3rd, Penn AS, Younger DS, Wolff M, Olarte MR, Lovelace RE, Rowland LP (1988) “Maximal” thymectomy for myasthenia gravis. Results. J Thorac Cardiovasc Surg 95(5):747–757

    PubMed  Google Scholar 

  3. Suzuki H, Yoshida S, Hiroshima K, Nakatani Y, Yoshino I (2010) Synchronous multiple thymoma: report of three cases. Surg Today 40(5):456–459. doi:10.1007/s00595-009-4080-z

    Article  PubMed  Google Scholar 

  4. Okada M, Tsubota N, Yoshimura M, Miyamoto Y, Sakamoto T (1998) Two cases of synchronous multiple thymoma. Surg Today 28(12):1323–1325. doi:10.1007/BF02482827

    Article  CAS  PubMed  Google Scholar 

  5. Mori T, Nomori H, Ikeda K, Yoshioka M, Kobayashi H, Iwatani K, Yoshimoto K, Iyama K (2007) Three cases of multiple thymoma with a review of the literature. Jpn J Clin Oncol 37(2):146–149. doi:10.1093/jjco/hyl147

    Article  PubMed  Google Scholar 

  6. Ishibashi H, Akamatsu H, Sunamori M (2003) Multiple thymoma with myasthenia gravis: report of a case. Surg Today 33(1):49–51. doi:10.1007/s005950300008

    Article  PubMed  Google Scholar 

  7. Kawaguchi K, Usami N, Uchiyama M, Ito S, Yasuda A, Yokoi K (2007) Triple thymoma with different histologic types. J Thorac Cardiovasc Surg 133(3):826–827. doi:10.1016/j.jtcvs.2006.10.030

    Article  PubMed  Google Scholar 

  8. Nomori H, Kobayashi K, Ishihara T, Suito T, Torikata C (1990) A case of multiple thymoma: the possibility of intra-thymic metastasis. Jpn J Clin Oncol 20(2):209–211

    CAS  PubMed  Google Scholar 

  9. Nakagawa K, Asamura H, Sakurai H, Watanabe S, Tsuta K (2014) Does the mode of surgical resection affect the prognosis/recurrence in patients with thymoma? J Surg Oncol 109(3):179–183. doi:10.1002/jso.23499

    Article  PubMed  Google Scholar 

  10. Network NCC (2013) NCCN clinical practice guidelines in oncology—thymomas and thymic carcinomas. V. 2

Download references

Author information

Authors and Affiliations

  1. Department of General Thoracic Surgery, Seirei Hamamatsu General Hospital, Sumiyoshi 2-12-12, Naka-ku, Hamamatsu, Shizuoka, 430-8558, Japan

    Tomonari Oki, Toru Nakamura & Futoru Toyoda

  2. Department of Pathology, Seirei Hamamatsu General Hospital, Sumiyoshi 2-12-12, Naka-ku, Hamamatsu, Shizuoka, 430-8558, Japan

    Yoshifumi Arai & Yoshiro Otsuki

Authors
  1. Tomonari Oki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toru Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshifumi Arai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiro Otsuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Futoru Toyoda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tomonari Oki.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

We routinely obtain general consent from every patient prior to surgery before using his or her clinical data. Written informed consent was not obtained from the patient for publication of this case report because this report is merely a retrospective case report without additional invasive examinations or treatments for a study.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oki, T., Nakamura, T., Arai, Y. et al. Metachronous multiple thymoma with different clinical behavior and pathological findings. Int Canc Conf J 5, 158–161 (2016). https://doi.org/10.1007/s13691-016-0249-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13691-016-0249-7

Keywords

Search

Navigation