Abstract
A 67-year-old man presented with a 142-mm right renal tumor with multiple lung metastases. Duodenum and ascending colon invasion were also suspected. Performance status did not permit surgical procedure at first visit. We started systemic therapy with a molecular targeted drug. Based on his prognostic risk factors, administration of temsirolimus was initiated, and his performance status improved enough to perform radical right nephrectomy with intestinal resection. Pathology confirmed clear cell renal cell carcinoma, pT4, with duodenum and ascending colon invasion. After surgery, temsirolimus administration was resumed. Eight and a half months after surgery, the patient developed progressive disease, and temsirolimus therapy was discontinued. As a second-line molecular targeted drug, axitinib was employed. Four and a half months after starting axitinib, the patient once again developed progressive disease, and we increased the dosage of axitinib. Currently, at 22 months after surgery, he is alive under axitinib treatment.
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Acknowledgments
The authors would like to thank Elizabeth Kiritani for English language assistance with the preparation of this report.
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The authors declare that they have no conflict of interest.
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Yagisawa, T., Kondo, T., Omae, K. et al. Combination of molecular targeted therapy and surgery for a patient with metastatic renal cell carcinoma with a poor prognosis. Int Canc Conf J 4, 138–142 (2015). https://doi.org/10.1007/s13691-014-0185-3
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DOI: https://doi.org/10.1007/s13691-014-0185-3