Abstract
This article describes a case of radiation-induced pyogenic vertebral osteomyelitis (PVO) after re-irradiation for para-aortic lymph node metastases in a patient with cervical cancer. A 62-year-old woman was admitted to our hospital with fever and severe back pain 4 months after re-irradiation (initially 56 Gy plus a secondary 50 Gy) of the para-aortic lymph nodes at the level of the fourth lumbar vertebra. Streptococcus group G was detected in a vertebral biopsy specimen and blood cultures. The patient was diagnosed with radiation-induced PVO, and intravenous antibiotic therapy was initiated. Symptoms improved significantly 2 weeks later. The patient was healthy with no evidence of relapse 5 years after the second course of radiotherapy.
References
Mylona E, Samarkos M, Kakalou E et al (2008) Pyogenic pyogenic vertebral osteomyelitis: a system review of clinical characteristics. Semin Arthritis Rheum 39:10–17
McHenry MC, Easley KA, Locker GA (2002) Pyogenic vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis 34:1342–1350
Werner Z (2010) Pyogenic vertebral osteomyelitis. N Engl J Med 362:1022–1029
Donovan DJ, Huynh TV, Purdom EB et al (2005) Osteoradionecrosis of the cervical spine resulting from radiotherapy for primary head and neck malignancies: operative and nonoperative management. J Neurosurg Spine 3:159–164
Cheung JPY, Wei WI, Luk KDK (2013) Cervical spine complications after treatment of nasopharyngeal carcinoma. Eur Spine J 22:584–592
Nabil S, Samman N (2012) Risk factors for osteoradionecrosis after head and neck radiation: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 113(1):54–69
Cunha MV, Al-Omair A, Atenafu EG et al (2012) Vertebral compression fracture (VCF) after spine stereotactic body radiation therapy (SBRT): analysis of predictive factors. Int J Radiat Oncol Biol Phys 84:343–349
Oya N, Kokubo M, Mizowaki T et al (2001) Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. Int J Radiat Oncol Biol Phys 51:87–93
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Takahashi, I., Kaneyasu, Y., Yamamoto, Y. et al. Radiation-induced pyogenic vertebral osteomyelitis after re-irradiation for para-aortic lymph node metastases in a patient with cervical cancer. Int Canc Conf J 3, 207–210 (2014). https://doi.org/10.1007/s13691-013-0145-3
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DOI: https://doi.org/10.1007/s13691-013-0145-3