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How to Treat Acne in Pregnant Women

  • Pregnancy Dermatoses and Fetal Exposure (A Ingber and Y Ramot, Section Editors)
  • Published:
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Abstract

Acne vulgaris is a common skin condition with 85 % lifetime prevalence. The prevalence and clinical characteristics of acne in pregnant women have not been studied intensively. The course of acne in pregnancy is highly variable, with many women experiencing exacerbation of their condition and some experiencing improvement. Topical medications are first line therapies for acne. In most cases of acne during pregnancy, whether it is presenting de novo or exacerbated by the pregnancy, both physicians and patients will prefer topical treatments, in order to avoid possible complications. However, safe systemic treatment options exist and should be considered for patients not responding to topical remedies. In this review, topical and systemic treatments appropriate for acne during pregnancy will be discussed, and their efficacy and safety will be appraised.

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References

  1. Tanghetti EA, Kawata AK, Daniels SR, Yeomans K, Burk CT, Callender VD. Understanding the burden of adult female acne. J Clin Aesthet Dermatol. 2014;7(2):22–30.

    PubMed Central  PubMed  Google Scholar 

  2. Ratzer M. The influence of marriage, pregnancy and childbirth on acne vulgaris. Br J Dermatol. 1964;76:165–8.

    Article  CAS  PubMed  Google Scholar 

  3. Dréno B, Blouin E, Moyse D, Bodokh I, Chantal Knol A, Khammari A. Acne in pregnant women: a French survey. Acta Derm Venereol. 2014;94(1):82–3.

    Article  PubMed  Google Scholar 

  4. Fuentelsaz V, Ara M, Corredera C, Lezcano V, Juberias P, Carapeto FJ. Rosacea fulminans in pregnancy: successful treatment with azithromycin. Clin Exp Dermatol. 2011;36(6):674–6. Epub 2011 Jun 30.

    Article  CAS  PubMed  Google Scholar 

  5. Zaeuglein, AL, Thiboutot, D. Acne vulgaris.In: Bolognia JL, Jorizzo JL, Schaffer JV (edt.) Dermatology. 2012, Elsvier limit. P 545-559

  6. Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O'Driscoll J, et al. The distribution of estrogen receptor beta is distinct to that of estrogen receptor alpha and the androgen receptor in human skin and the pilosebaceous unit. J Investig Dermatol Symp Proc. 2003;8:100–3.

    Article  CAS  PubMed  Google Scholar 

  7. Kuijper EA, Ket JC, Caanen MR, Lambalk CB. Reproductive hormone concentrations in pregnancy and neonates: a systematic review. Reprod Biomed Online. 2013;27(1):33–63. Epub 2013Mar 25.

    Article  CAS  PubMed  Google Scholar 

  8. Farage MA, Neill S, MacLean AB. Physiological changes associated with the menstrual cycle: a review. Obstet Gynecol Surv. 2009;64(1):58–72.

    Article  PubMed  Google Scholar 

  9. Murase JE, Heller MM, Butler DC. Safety of dermatologic medications in pregnancy and lactation part I. Pregnancy J Am Acad Dermatol. 2014;70(3):401–14.

    Google Scholar 

  10. Leyden JJ, McGinley KJ, Cavalieri S, Webster GF, Mills OH, Kligman AM. Propionibacterium acnes resistance to antibiotics in acne patients. J Am Acad Dermatol. 1983;8(1):41–5.

    Article  CAS  PubMed  Google Scholar 

  11. Katsamba A, Dessinioti C. New and emerging treatments in dermatology: acne. Dermatol Ther. 2008;21(2):86–95.

    Article  Google Scholar 

  12. Khodaeiani E, Fouladi RF, Yousefi N, Amirnia M, Babaeinejad S, Shokri J. Efficacy of 2 % metronidazole gel in moderate acne vulgaris. Indian J Dermatol. 2012;57(4):279–81.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Koss CA, Baras DC, Lane SD, Aubry R, Marcus M, Markowitz LE, et al. Investigation of metronidazole use during pregnancy and adverse birth outcomes. Antimicrob Agents Chemother. 2012;56(9):4800–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Stotland M, Shalita AR, Kissling RF. Dapsone 5 % gel: a review of its efficacy and safety in the treatment of acne vulgaris. Am J Clin Dermatol. 2009;10(4):221–7.

    Article  PubMed  Google Scholar 

  15. Pickert A, Raimer S. An evaluation of dapsone gel 5 % in the treatment of acne vulgaris. Expert Opin Pharmacother. 2009;10(9):1515–21.

    Article  CAS  PubMed  Google Scholar 

  16. Thiboutot D. Versatility of azaleic acid 15 % gel in treatment of inflammatory acne vulgaris. J Drugs Dermatol. 2008;7:13–6.

    PubMed  Google Scholar 

  17. Sieber MA, Hegel JKE. Azelaic acid: properties and mode of action. Skin Pharmacol Physiol. 2014;27 suppl 1:9–17.

    Article  CAS  PubMed  Google Scholar 

  18. Gollnick H, Schramm M. Topical drug treatment in acne. Dermatology. 1998;196(1):119–25.

    Article  CAS  PubMed  Google Scholar 

  19. Morsches B, Holzmann H. Studies on the percutaneous absorption of benzoyl peroxide [in German]. Arzneimittelforschung. 1982;32:298–300.

    CAS  PubMed  Google Scholar 

  20. Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol. 2003;4(7):473–92.

    Article  PubMed  Google Scholar 

  21. Ishii N. Executive committee of guideline for the diagnosis. Guideline for the diagnosis and treatment of scabies in Japan (second edition). J Dermatol. 2008;35(6):378–93.

    Article  PubMed  Google Scholar 

  22. Kaminaka C, Uede M, Matsunaka H, Furukawa F, Yamomoto Y. Clinical evaluation of glycolic acid chemical peeling in patients with acne vulgaris: a randomized, double-blind, placebo-controlled, split-face comparative study. Dermatol Surg. 2014;40(3):314–22. Epub 2014 Jan 21.

    Article  CAS  PubMed  Google Scholar 

  23. Panchaud A, Csajka C, Merlob P, Schaefer C, Berlin M, De Santis M, et al. Pregnancy outcome following exposure to topical retinoids. J Clin Pharmacol. 2012;52(12):1844–51.

    Article  CAS  PubMed  Google Scholar 

  24. Fenner JA, Wiss K, Levin NA. Oral cephalexin for acne vulgaris: clinical experience with 93 patients. Ped Dermatol. 2008;25(2):179–83.

    Article  Google Scholar 

  25. Amin K, Riddle CC, Aires DJ, Schweiger ES. Common and alternate oral antibiotic therapies for acne vulgaris: a review. J Drugs Dermatol. 2007;6(9):873–80.

    PubMed  Google Scholar 

  26. Maleszka R, Turek Urasinska K, Oremus M, Vukovic J, Barsic B. Pulsed azithromycin treatment is as effective and safe as 2-week-longer daily doxycycline treatment of acne vulgaris: a randomized, double-blind, noninferiority study. Skinmed. 2011;9(2):86–94.

    PubMed  Google Scholar 

  27. Antonio JR, Pegas JR, Cestari TF, Do Nascimento LV. Azithromycin pulses in the treatment of inflammatory and pustular acne: efficacy, tolerability and safety. J Dermatolog Treat. 2008;19(4):210–5.

    Article  CAS  PubMed  Google Scholar 

  28. McCormack WM, George H, Donner A, Kodgis LF, Alpert S, Lowe EW, et al. Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother. 1977;12(5):630–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Scheinfeld N. Dissecting cellulitis (perifolliculitis capitis abscedens et suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppurativa. Dermatol Online J. 2014;20(5):22692.

    PubMed  Google Scholar 

  30. Hassanzadeh P, Bahmani M, Mehrabani D. Bacterial resistance to antibiotics in acne vulgaris: an in vitro study. Indian J Dermatol. 2008;53(3):122–4.

    Article  PubMed Central  PubMed  Google Scholar 

  31. Nosten F, McGready R, d'Alessandro V, Bonnel A, Verhoeff F, Menandez C, et al. Anti malarial drugs in pregnancy: a review. Cur Drug Saf. 2006;1(1):1–15.

    Article  CAS  Google Scholar 

  32. Verma KC, Saini AS, Dhamija SK. Oral zinc sulphate therapy in acne vulgaris: a double-blind trial. Acta Derm Venereol. 1980;60(4):337–40.

    CAS  PubMed  Google Scholar 

  33. Dreno B, Moyse D, Alirezai M, Amblard P, Auffnet N, Beylot C, et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology. 2001;203(2):135–40.

    Article  CAS  PubMed  Google Scholar 

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L Horev declares no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Liran Horev.

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Horev, L. How to Treat Acne in Pregnant Women. Curr Derm Rep 3, 135–140 (2014). https://doi.org/10.1007/s13671-014-0084-z

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  • DOI: https://doi.org/10.1007/s13671-014-0084-z

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