Cancer (MF Leitzmann, Section Editor)

Current Nutrition Reports

, Volume 2, Issue 1, pp 10-18

First online:

Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis

  • B. S. Tyler CulpepperAffiliated withDepartment of Microbiology and Cell Sciences, IFAS
  • , Volker MaiAffiliated withDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine and Emerging Pathogens Institute, University of Florida Email author 


The contributions of the commensal gut microbiota to the maintenance of human health have long been contemplated. Whereas earlier studies were limited by an inability to analyze microbiota in sufficient depth, recent advances in the application of high throughput sequencing have allowed for an in-depth microbiota analysis in large numbers of individuals. Multiple lines of evidence have been generated that are supportive of an active role of gut microbiota in colorectal carcinogenesis. Although no single microbe has yet been shown to be causally linked to CRC, contributions of the gut microbiota to colorectal carcinogenesis are evident. Further advances in the field, which should include prospective studies in high-risk cohorts, should generate the data needed to start translating findings into microbiota-based screening and prevention regimen that can help to reduce the burden of CRC.


Gut Flora Microbiota Microflora Commensal Carcinogenesis Neoplastic CRC Probiotics Prebiotics Colon Cancer Intestinal