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Bronchiectasis and connective tissue diseases

  • Bronchiectasis (G Tino, Section Editor)
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Abstract

Connective tissue diseases (CTD) encompass a range of heritable and autoimmune conditions that are well known for their systemic effects. While these conditions have been observed to impact the lung in myriad fashion, bronchiectasis remains an often overlooked pulmonary complication, despite the fact that the prevalence of bronchiectasis can be as high as 60 % in patients with rheumatoid arthritis. In this review, we cover the epidemiology and clinical findings of bronchiectasis in autoimmune CTDs such as rheumatoid arthritis and Sjögren’s syndrome and heritable CTDs such as Marfan syndrome and Ehlers-Danlos syndrome. We propose that changes in the oral, gut, and lung microbiome may influence autoimmunity and the structural integrity of the airway, thus leading to bronchiectasis.

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Acknowledgments

This research was supported in part by the Intramural Research Program of the NIH, National Heart, Lung, and Blood Institute.

Author information

Authors and Affiliations

  1. Division of Respiratory Medicine, Department of Medicine, and Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Room 166-1088 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada

    Janice M. Leung

  2. Pulmonary Clinical Medicine Section, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, MSC 1454, Building 10-CRC, Room 6-3130, Bethesda, MD, 20892, USA

    Kenneth N. Olivier

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  1. Janice M. Leung
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  2. Kenneth N. Olivier
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Correspondence to Janice M. Leung or Kenneth N. Olivier.

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Kenneth Olivier and Janice Leung declare no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Bronchiectasis

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Leung, J.M., Olivier, K.N. Bronchiectasis and connective tissue diseases. Curr Pulmonol Rep 5, 169–176 (2016). https://doi.org/10.1007/s13665-016-0154-8

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  • DOI: https://doi.org/10.1007/s13665-016-0154-8

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