Regular Article

Natural Products and Bioprospecting

, Volume 2, Issue 4, pp 145-149

Open Access This content is freely available online to anyone, anywhere at any time.

Five new mexicanolide type limonoids from Heynea trijuga

  • Wei YangAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesGraduate University of Chinese Academy of Sciences
  • , Ling-Mei KongAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesGraduate University of Chinese Academy of Sciences
  • , Shi-Fei LiAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesGraduate University of Chinese Academy of Sciences
  • , Yan LiAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences
  • , Yu ZhangAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Email author 
  • , Hong-Ping HeAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Email author 
  • , Xiao-Jiang HaoAffiliated withState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

Abstract

Five new mexicanolide-type limonoids, heytrijunolides A–E (1–5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549 human tumor cell lines with the IC50 values of 21.88, 20.66 and 12.70 µM, respectively.
http://static-content.springer.com/image/art%3A10.1007%2Fs13659-012-0040-1/MediaObjects/13659_2012_40_Fig1_HTML.gif

Keywords

Heynea trijuga Meliaceae limonoids mexicanolide-type heytrijunolide