Oriental Pharmacy and Experimental Medicine

, Volume 13, Issue 2, pp 127–131

Rhododendron arboreum (Ericaceae): immunomodulatory and related toxicity studies

  • Pankaj Kumar Sonar
  • Ranjit Singh
  • Anju Verma
  • Shailendra K. Saraf
Research Article

DOI: 10.1007/s13596-013-0104-8

Cite this article as:
Sonar, P.K., Singh, R., Verma, A. et al. Orient Pharm Exp Med (2013) 13: 127. doi:10.1007/s13596-013-0104-8

Abstract

In the present study, an attempt was made to evaluate the extract of the leaves of Rhododendron arboreum for immunomodulatory activity and related hepatotoxicity. Alcoholic extract of the leaves of R. arboreum was prepared by hot percolation method. Levamisole was used as the standard drug. The parameters like, humoral immune response, cell mediated immune response and total leukocyte counts (TLC) were assessed in the antigenically challenged mice with sheep RBC (SRBC). Liver function tests like total bilirubin, SGPT and SGOT were also evaluated. The, orally administered alcoholic extract of the leaves showed a significant suppression of the immune responses, in a dose dependent manner. The extract at the maximum dose (100 mg/kg) was found to possess higher immunosuppressant effect in comparison with control and levamisole (p < 0.001). No significant difference was observed in the weights of liver and spleen of extract-treated mice in comparison with levamisole and vehicle treated mice. Liver function tests of extract-treated mice were also statistically insignificant in comparison with levamisole and vehicle-treated mice. Thus, it can be concluded that the alcoholic extract of R. arboreum is an effective and safe immunosuppressive agent.

Keywords

R. arboreum Haemagglutination DTH Phagocytosis SRBC 

Copyright information

© Institute of Oriental Medicine, Kyung Hee University 2013

Authors and Affiliations

  • Pankaj Kumar Sonar
    • 1
    • 4
  • Ranjit Singh
    • 2
  • Anju Verma
    • 3
  • Shailendra K. Saraf
    • 1
  1. 1.Faculty of PharmacyBabu Banarasi Das Northern India Institute of TechnologyLucknowIndia
  2. 2.Government College of PharmacyShimlaIndia
  3. 3.Divison of PharmacognosySaroj Institute of Technology and ManagementLucknowIndia
  4. 4.Pharmaceutical Chemistry, Faculty of PharmacyBabu Banarasi Das Northern India Institute of TechnologyLucknowIndia

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