Research Article

Oriental Pharmacy and Experimental Medicine

, Volume 12, Issue 2, pp 107-111

Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells

  • In-Young ChoiAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , You-Jeong KimAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Ji-Ye KeeAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Min-Chol KimAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Dong-Jin LeeAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Sung-One ChoAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Jang-Ho KoAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Dae-Seung KimAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
  • , Yong-Deok JeonAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
    • , Cheol-Hee YoonAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University
    • , Yun-Jum ParkAffiliated withDivision of Horticulture and Pet Animal-Plant Science, Wonkwang University
    • , Jae-Young UmAffiliated withCollege of Oriental Medicine, Kyung Hee University
    • , Seung-Heon HongAffiliated withDepartment of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University Email author 

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Abstract

Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The incidence and prevalence rates of IBD in Korea have been increasing rapidly during the past decades. In this study, we investigated regulatory effect of leaf of a mulberry tree (Moraceae) called Gwasang-No.2 in Korea. Leaf of Gwasang-No.2 (Gwa.L) inhibited the inflammatory responses on dextran sulfate sodium induced ulcerative colitis in mice and the production of nitrite oxide from lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages. Gwa.L inhibited IL-6 and IL-8 production from HMC-1 cells without cytotoxic effects on cell viability. These results may be relevant for future pharmacological or dietary interventions in patients with ulcerative colitis.

Keywords

Mulberry leaf Ulcerative colitis DSS Nitrite oxide Anti-inflammation