Oriental Pharmacy and Experimental Medicine

, Volume 12, Issue 2, pp 107–111

Mori Folium regulates DSS-induced ulcerative colitis in mice and cytokine production in mast cells

  • In-Young Choi
  • You-Jeong Kim
  • Ji-Ye Kee
  • Min-Chol Kim
  • Dong-Jin Lee
  • Sung-One Cho
  • Jang-Ho Ko
  • Dae-Seung Kim
  • Yong-Deok Jeon
  • Cheol-Hee Yoon
  • Yun-Jum Park
  • Jae-Young Um
  • Seung-Heon Hong
Research Article

DOI: 10.1007/s13596-012-0055-5

Cite this article as:
Choi, IY., Kim, YJ., Kee, JY. et al. Orient Pharm Exp Med (2012) 12: 107. doi:10.1007/s13596-012-0055-5
  • 188 Downloads

Abstract

Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The incidence and prevalence rates of IBD in Korea have been increasing rapidly during the past decades. In this study, we investigated regulatory effect of leaf of a mulberry tree (Moraceae) called Gwasang-No.2 in Korea. Leaf of Gwasang-No.2 (Gwa.L) inhibited the inflammatory responses on dextran sulfate sodium induced ulcerative colitis in mice and the production of nitrite oxide from lipopolysaccharide and interferon-gamma stimulated mouse peritoneal macrophages. Gwa.L inhibited IL-6 and IL-8 production from HMC-1 cells without cytotoxic effects on cell viability. These results may be relevant for future pharmacological or dietary interventions in patients with ulcerative colitis.

Keywords

Mulberry leafUlcerative colitisDSSNitrite oxideAnti-inflammation

Copyright information

© Institute of Oriental Medicine, Kyung Hee University 2012

Authors and Affiliations

  • In-Young Choi
    • 1
  • You-Jeong Kim
    • 1
  • Ji-Ye Kee
    • 1
  • Min-Chol Kim
    • 1
  • Dong-Jin Lee
    • 1
  • Sung-One Cho
    • 1
  • Jang-Ho Ko
    • 1
  • Dae-Seung Kim
    • 1
  • Yong-Deok Jeon
    • 1
  • Cheol-Hee Yoon
    • 1
  • Yun-Jum Park
    • 2
  • Jae-Young Um
    • 3
  • Seung-Heon Hong
    • 1
  1. 1.Department of Oriental Pharmacy, College of Pharmacy and Wonkwang Oriental Medicines Research InstituteWonkwang UniversityIksanRepublic of Korea
  2. 2.Division of Horticulture and Pet Animal-Plant ScienceWonkwang UniversityIksanRepublic of Korea
  3. 3.College of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea