Abstract
Human lung cancer is the leading cause of cancer motility worldwide, with nearly 1.4 million deaths each year, among which non-small cell lung cancer (NSCLC) accounts for almost 85 % of this disease. The discovery of microRNAs (miRNAs) provides a new avenue for NSCLC diagnostic and treatment regiments. Currently, a large number of miRNAs have been reported to be associated with the progression of NSCLC, among which serum miR-137 has been examined to be down-regulated in NSCLC patients. However, the function of miR-137 on NSCLC cells migration and invasion and the relative mechanisms were less known. Here, we found that ectopic expression of miR-137 could inhibit cell proliferation, induce cell apoptosis, and suppress cell migration and invasion in NSCLC cell line A549. Moreover, we found that paxillin (PXN) was a target gene of miR-137 in NSCLC cells and restored expression of PXN abolished the miR-137-mediated suppression of cell migration and invasion. Taken together, our results showed that miR-137 acted as a tumor suppressor in NSCLC by targeting PXN, and it may provide novel diagnostic and therapeutic options for human NSCLC clinical operation in future.
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This work was supported by the Affiliated Hospital of Binzhou Medical University.
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Y. Bi and Y. Han contributed equally to this work.
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Bi, Y., Han, Y., Bi, H. et al. miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin . Human Cell 27, 95–102 (2014). https://doi.org/10.1007/s13577-013-0085-4
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DOI: https://doi.org/10.1007/s13577-013-0085-4