Bile acids for cachexia therapy
In a recent letter , Dr. Kapoor commented on our paper describing the effects of ursodeoxycholic acid (UDCA) in a model of severe cancer cachexia . Dr. Kapoor is obviously correct in stating that there is emerging data showing that bile acids such as UDCA may be beneficial in gastrointestinal cancers by attenuating cancer progression. However, in our study, the aim was to characterize the effects of UDCA on cachexia development and progression in a cancer model, in which the effects of UDCA on tumor growth would be minimal to avoid biased results on cachexia development through a possible antineoplastic effect. Therefore, we chose to use the Yoshida hepatoma AH-130 rat model, in which rats develop severe cachexia very fast, but drug effects on proliferation—aside from chemotherapeutics—have been shown to be minimal, even when using growth factors like IGF-1 . Indeed, UDCA had no effect on tumor proliferation in our model, but unfortunately its anti-cachexia effects ...
- Kapoor S. Ursodeoxycholic acid and its emerging role in attenuation of tumor growth in gastrointestinal malignancies. J Cachexia Sarcopenia Muscle. 2012;3. doi:10.1007/s13539-012-0091-5.
- Tschirner A, von Haehling S, Palus S, Doehner W, Anker SD, Springer J. Ursodeoxycholic acid treatment in a rat model of cancer cachexia. J Cachexia Sarcopenia Muscle. 2012;3:31–6. doi:10.1007/s13539-011-0044-4. CrossRef
- Schmidt K, von Haehling S, Doehner W, Palus S, Anker SD, Springer J. IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia. J Cachexia Sarcopenia Muscle. 2011;2:105–9. doi:10.1007/s13539-011-0029-3. CrossRef
- Chung GE, Yoon JH, Lee JH, Kim HY, Myung SJ, Yu SJ, et al. Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth. Oncol Rep. 2011;25:1739–46.
- Bile acids for cachexia therapy
Journal of Cachexia, Sarcopenia and Muscle
Volume 3, Issue 4 , p 279
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- 1. Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany
- 2. Center for Cardiovascular Research, Charite Medical School, Campus Mitte, Hessische Str. 3-4, 10115, Berlin, Germany
- 3. Norwich Medical School, University of East Anglia, Norwich, UK