Abstract
We present an electronic sensor in the molecular scale, which is very sensitive for detection and sensing of DNA characteristics and DNA activities in particular activities between DNA duplex and any protein. Here, the device shows that DNA is electronically inserted to be on the same time as an electrical device transducer and as a biological target in a carbon nanotube-DNA-carbon nanotube electronic sensor. We have performed a DNA binding through an amide group by the electron transfer through amide group. The presented device has shown an efficient and rapid procedure to bind the electrical vulnerability of DNA with the detection of enzymatic effectiveness leading to high efficient biosensor.
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A. Shankar, J. Mittal, A. Jagota, Binding between DNA and carbon nanotubes strongly depends upon sequence and chirality. Langmuir 30(11), 3176–3183 (2014)
E.N. Andre, M. Lutz, V. Darrell, X. Tian, M.V. Eric, P. Hoek, F.K. Somasundaran, C. Vince, T. Mike, Understanding bio-physicochemical interactions at the nano–bio interface. Nat. Mater. 8, 543–557 (2009)
D.P.E. Smith, Quantum point-contact switches. Science 269, 371–373 (1995)
K. Terabe, T. Hasegawa, T. Nakayama, M. Aono, Quantized conductance atomic switch. Nature 433, 47–50 (2005)
C. N. R. Rao, A. Govindaraj, Nanotubes and Nanowires, RSC publishing, 2011
R.J. Chen, S. Bangsaruntip, K.A. Drouvalakis, N.W.S. Kam, M. Shim, Y. Li, W. Kim, P.J. Utz, H. Dai, Proc. Natl. Acad. Sci. U. S. A. 100, 4984 (2003)
Ali Afzali-Ardakani, Gustavo A. Stolovitzky, Deqiang Wang, Integrated carbon nanotube field effect transistor and nanochannel for sequencing, Publication number US8969118 B2.
S. Sorgenfrei, C.-Y. Chiu, R.L. Gonzalez Jr., Y.-J. Yu, P. Kim, C. Nuckolls, K.L. Shepard, Nat. Nanotechnol. 11, 1093 (2011)
Nikolai Dontschuk, Alastair Stacey, Anton Tadich, Kevin J. Rietwyk, Alex Schenk, Mark T. Edmonds, Olga Shimoni, Chris I. Pakes, Steven Prawer & Jiri Cervenka (2015) A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases, Nature Communications, 6, Article number:6563 doi:10.1038/ncomms7563.
Paul A. Rhodes, Samuel M. Khamis, Hybrid sensor array, Publication number, US20120028820 A1, 2012
K. Balasubramanian, M. Burghard, Anal. Bioanal. Chem. 2006 385, 452
C.B. Jacobs, M.J. Peairs, B.J. Venton, Anal. Chim. Acta 662, 105 (2010)
M.Y. Sfeir, T. Beetz, F. Wang, L. Huang, X.M.H. Huang, M. Huang, J. Hone, S. O’Brien, J.A. Misewich, T.F. Heinz, L. Wu, Y. Zhu, L.E. Brus, Optical spectroscopy of individual single-walled carbon nanotubes of defined chiral structure. Science 312, 554–556 (2006)
R.A. Villamizar, A. Maroto, F. Xavier Rius, Improved detection of Candida albicans with carbon nanotube field-effect transistors. Sensors Actuators B 136, 451–457 (2009)
X. Guo, A.A. Gorodetsky, J. Hone, J.K. Barton, C. Nuckolls, Nat. Nanotechnol. 3, 163 (2008)
J. Kong, N. Franklin, C. Zhou, M. Chapline, S. Peng, K. Cho, et al., Nanotube molecular wires as chemical sensors. Science 287, 622 (2000)
R.A. Villamizar, A. Maroto, F.X. Riusa, I. Inza, M.J. Figueras, Fast detection of Salmonella Infantis with carbon nanotube field effect transistors. Biosens. Bioelectron. 24, 279–283 (2008)
J. Oh, S. Yoo, Y.W. Chang, K. Lim, K.H. Yoo, Carbon nanotube-based biosensor for detection hepatitis B. Curr. Appl. Phys. 9, E229–E231 (2009)
S.O. Kelley, J.K. Barton, Science 283, 375 (1999)
J.C. Genereux, J.K. Barton, Chem. Rev. 110, 1642 (2010)
P. Renbaum, D. Abrahamove, A. Fainsod, G. Wilson, S. Rottem, A. Razin, Nucleic Acids Res. 18, 1145 (1990)
A. Razin, P. Renbaum, J. Mol. Biol. 248, 19 (1995)
S. Klimasauskas, E. Weinhold, S. Serva, E. Merkiene, G. Vilkaitis, J. Biol. Chem. 276, 20924 (2001)
A.K. Dubey, R.J. Roberts, Nucleic Acids Res. 20, 3167 (1992)
S. Abdalla, Prog. Biophys. Mol. Biol. 106, 485–497 (2011)
B.Q. Xu, N.J.J. Tao, Science 301, 1221 (2003)
Y. Otsuka, H.-y. Lee, G. Jian-hua, J.-O. Lee, K.-H. Yoo, H. Tanaka, H. Tabata, T. Kawai, Influence of humidity on the electrical conductivity of synthesized DNA film on nanogap electrode. Jpn. J. Appl. Phys. 41, 891. doi:10.1143/JJAP.41.891
D. Yang, L. Wang, Q. Zhao, S. Li, Fabrication of single-walled carbon nanotubes (SWNTs) field-effect transistor (FET) biosensor. BMEI 3rd 4, 1482–1485 (2010)
T. Kleine-Ostmann, C. Jordens, K. Baaske, T. Weimann, M.H. de Angelis, M. Koch, Appl. Phys. Lett. 88, 102102 (2006)
J.O. Lee, J.J. Kim, S.K. Kim, Journal of the Korean Physical Society 39, S56–S58 (2001)
M. Zheng, A. Jagota, E.D. Semke, B.A. Diner, R.S. McLean, S.R. Lustig, R.E. Richardson, N.G. Tassi, Nat. Mater. 2, 338–342 (2003)
G. Lu, P. Maragakis, E. Kaxiras, Nano Lett. 5, 897–900 (2005)
Y. Ma, S.R. Ali, A.S. Dodoo, H. He, Enhanced sensitivity for biosensors: multiple functions of DNA-wrapped single-walled carbon nanotubes in self-doped polyaniline nanocomposites. J. Phys. Chem. B 110(33), 16359–16365 (2006)
P.G. Collins, K. Bradley, M. Ishigami, A. Zettl, Science 287, 1801–1839 (2000)
X. Cui, M. Freitag, R. Martel, L. Brus, P. Avouris, Controlling energy-level alignments at carbon nanotube/Au contacts. Nano Lett. 3(6), 783–787 (2003)
F. Léonard, J. Tersoff, Phys. Rev. Lett. 84, 4693 (2000)
J. Chen, C. Klinke, A. Afzali-Ardakani, P. Avouris, Charge-transfer doped and self-aligned carbon nanotube transistors. Appl. Phys. Lett. 86, 108–123 (2005)
A. Javey, J. Guo, Q. Wang, M. Lundstrom, H. Dai, Ballistic carbon nanotube transistors. Nature 424, 654–657 (2003)
S. Rosenblatt, Y. Yaish, J. Park, J. Gore, V. Sazonova, P.L. McEuen, High performance electrolyte gated carbon nanotube transistors. Nano Lett. 2(8), 869–872 (2002)
Y.-M. Lin, J. Appenzeller, Z. Chen, Z.-G. Chen, H.-M. Cheng, P. Avouris, High-performance dual-gate carbon nanotube FETs with 40-nm gate length. ELECTRON DEVICE LETTERS 26(11) (2005)
Y. Wu, S.K.M. Nalluri, R.M. Young, M.D. Krzyaniak, E.A. Margulies, J. Fraser Stoddart, M.R. Wasielewski, Charge and spin transport in an organic molecular square. Angew. Chem. Int. Ed. 54(41), 11971–11977 (2015)
S. Abdalla, F. Marzouki, Concepts on charge transfer through naturally vibrating DNA molecule. Gene 509(1), 24–37 (2012)
S. Abdalla, S.D. Jastaniah, Electrical conduction of calf-thymus DNA molecules. International Journal of Nano and Biomaterials 2(1–5), 299–306 (2009)
S. Abdalla, F.M. Al-Marzouki, A.A. Al-Ghamdi, Robust electrical contacts to organic molecules (DNA) via organic covalent bond. MITTEILUNGEN KLOSTERNEUBURG 64, 12 (2014)
S. Abdalla, Electric breakdown through nano dielectric films. Editorial J Material Sci. Eng 1, 3 (2012)
K. Forinash, A.R. Bishop, P. Lomdahl, Nonlinear dynamics in a double chain model of DNA, chapter nonlinearity with disorder of the series. Springer Proceedings in Physics 67, 190–202
A.A. Kletsova, E.G. Glukhovskoya, A.S. Chumakova, J.V. Ortiz, Ab initio electron propagator calculations of transverse conduction through DNA nucleotide bases in 1-nm nanopore corroborate third generation sequencing. Biochim. Biophys. Acta Gen. Subj. 1860(A), 140–145 (2016)
L. Xiang, J.L. Palma, C. Bruot, V. Mujica, M.A. Ratner, N. Tao, Intermediate tunnelling–hopping regime in DNA charge transport. Nat. Chem. 7, 221–226 (2015)
D.T. Odom, E.A. Dill, J.K. Barton, Robust charge transport in DNA double crossover assemblies. Chem. Biol. 7(7), 475–481 (2000)
E.L. Albuquerque, P.W. Mauriz, D.A. Moreira, Electronic transport in double-strand DNA segments. J. Phys. Conf. Ser. 100, 052060 (2008)
D. Mishra, S. Pal, Ionization potential and structure relaxation of adenine, thymine, guanine and cytosine bases and their base pairs: a quantification of reactive sites. Journal of Molecular Structure: THEOCHEM 902(1–3), 96–102 (2009)
Y. Li, J.M. Artés, J. Hihath, Long-range charge transport in adenine-stacked RNA:DNA hybrids. Small 12(4), 432–437 (2016 Jan). doi:10.1002/smll.201502399 Epub 2015 Nov 24
S. Abdalla, Electrical conduction through DNA molecule. Progress in Biophysics and Molecular Biology 106(3), 485–497 (2011)
W.A. Flavahan, Y. Drier, B.B. Liau, S.M. Gillespie, A.S. Venteicher, A.O. Stemmer-Rachamimov, M.L. Suvà, B.E. Bernstein, Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature 529, 110–125 (2016)
O. Lopatynska, A. Lopatynskyi, V. Chegel, L. Poperenko, Theoretical understanding of the SPR sensor response on the protein adsorption. JJAP Conf. Proc. 4(011501) (2016). doi:10.7567/JJAPCP.4.011501
P. Sungjun, W. Gunuk, C. Byungjin, K. Yonghun, S. Sunghoon, J. Yongsung, Y. Myung-Han, L. Takhee, Nat. Nanotechnol., 7,438–7,442 (2012). doi:10.1038/nnano.2012.81 4
M. Radosavljević, S. Heinze, J. Tersoff, P. Avouris, Drain voltage scaling in carbon nanotube transistors. Appl. Phys. Lett. 83, 2435
L. Bogner, Z. Yang, M. Corso, R. Fitzner, P. Bäuerle, K.J. Franke, J.I. Pascual, P. Tegeder, Electronic structure and excited state dynamics in a dicyanovinyl-substituted oligothiophene on Au (111). Phys. Chem. Chem. Phys. 17, 27118–27126 (2015)
Acknowledgements
This project was supported by the NSTIP Strategic Technologies Program (MAAREFAH) in the Kingdom of Saudi Arabia—Project No. (12-NAN2270-03); the authors also acknowledge with thanks the Science and Technology Unit, King Abdulaziz University, for the technical support
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Abdalla, S., Al-Marzouki, F.M. & Al-Ghamdi, A.A. Field Effect Transistor Using Carbon Nanotubes and DNA as Electrical Gate. Braz J Phys 47, 34–41 (2017). https://doi.org/10.1007/s13538-016-0473-9
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DOI: https://doi.org/10.1007/s13538-016-0473-9