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Modulation of paraoxonase activity (PON)-1 by xanthone in sub chronic exposure of orgnophosphate: Antioxidant in dichorvos intoxicity

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Abstract

This research aims to find out the levels of xanthone in mangosteen pericarp extract (MPE) and to prove the ability of xanthone in modulating the activity of paraoxonase-1 (PON-1), reduce oxidized-low density lipoprotein (ox-LDL) and increase the levels of acetylcholinesterase (AChE) serum in animal model with organophosphat subchronic and subcutaneous exposure. This research is a true experimental laboratory with in vivo approach to post-test with control group, using 25 animal models of Wistar strain of Rattus novergicus, were exposed to dichlorvos as organophosphates (2 mg/kgBW/day) for 21 days. Those animal models are divided into no exposure group, organophosphate exposure group, and organophosphate exposure plus administration of xanthone groups. The parameters (levels of PON-1, ox-LDL and AChE measured by ELISA Test. The results showed that administration of xanthone significantly increased the levels of AChE, decreased levels of ox-LDL and PON-1.

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Authors and Affiliations

  1. Department of Biomedical, Faculty of Medicine, Brawijaya University, Malang, Indonesia

    Titin Andri Wihastuti

  2. Department of Cardiology, Faculty of Medicine, Brawijaya University, Malang, Indonesia

    Djanggan Sargowo

  3. Department of Cardiology, Faculty of Medicine, Syiah Kuala University, Aceh, Indonesia

    Teuku Heriansyah

  4. Brawijaya University, Malang, Indonesia

    Grace Rahmawati & Yuni Hendrati Sulfia

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  1. Titin Andri Wihastuti
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  2. Djanggan Sargowo
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Correspondence to Titin Andri Wihastuti.

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Wihastuti, T.A., Sargowo, D., Heriansyah, T. et al. Modulation of paraoxonase activity (PON)-1 by xanthone in sub chronic exposure of orgnophosphate: Antioxidant in dichorvos intoxicity. Toxicol. Environ. Health Sci. 7, 136–142 (2015). https://doi.org/10.1007/s13530-015-0232-2

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  • DOI: https://doi.org/10.1007/s13530-015-0232-2

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