Aberrant microRNA expression and its implications in the pathogenesis of leukemias
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MicroRNAs (miRNAs) are a class of non-coding, endogenous, small RNAs that negatively regulate gene expression by inducing degradation or translational inhibition of target mRNAs. Aberrant expression of miRNAs appears to be a common characteristic of hematological malignancies including leukemias.
Here we review the available data supporting a role of aberrant expression of miRNAs in the pathogenesis of leukemias including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL).
The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis, and therapy of leukemia. Since miRNAs can function as either oncogenes or tumor suppressor genes in leukemogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for leukemia therapy by either inhibiting or augmenting their activity.
- Aberrant microRNA expression and its implications in the pathogenesis of leukemias
Volume 35, Issue 5 , pp 317-334
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Expression signature
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Chronic myeloid leukemia
- Chronic lymphocytic leukemia
- Author Affiliations
- 1. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, 1411713116, Tehran, Iran
- 2. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- 3. Faculty of Biological Sciences, Shahid Beheshti University, G.C., Tehran, Iran
- 4. Department of Hematology, School of Medical Sciences, Tarbiat Modares University, P. O. Box: 14115-331, Tehran, Iran