Journal of NeuroVirology

, Volume 18, Issue 4, pp 247–255

Accelerated aging and human immunodeficiency virus infection: Emerging challenges of growing older in the era of successful antiretroviral therapy

Authors

  • Ramona Bhatia
    • Northwestern University Feinberg School of MedicineDivision of Infectious Diseases
  • Patrick Ryscavage
    • Institute of Human VirologyUniversity of Maryland School of Medicine
    • Northwestern University Feinberg School of MedicineDivision of Infectious Diseases
Review

DOI: 10.1007/s13365-011-0073-y

Cite this article as:
Bhatia, R., Ryscavage, P. & Taiwo, B. J. Neurovirol. (2012) 18: 247. doi:10.1007/s13365-011-0073-y

Abstract

HIV-infected patients are living longer as a result of potent antiretroviral therapy. Immuno-inflammatory phenomena implicated in the normal aging process, including immune senescence, depreciation of the adaptive immune system, and heightened systemic inflammation are also pathophysiologic sequelae of HIV infection, suggesting HIV infection can potentiate the biological mechanisms of aging. Aging HIV-infected patients manifest many comorbidities at earlier ages, and sometimes with more aggressive phenotypes compared to seronegative counterparts. In this review, we describe relevant biologic changes shared by normal aging and HIV infection and explore the growing spectrum of clinical manifestations associated with the accelerated aging phenotype in HIV-infected individuals.

Keywords

HIV Aging Immune senescence Chronic inflammation Cardiovascular Frailty

Copyright information

© Journal of NeuroVirology, Inc. 2011